Registration Dossier
Registration Dossier
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EC number: 208-757-0 | CAS number: 540-80-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
- Principles of method if other than guideline:
- no guideline specified
- GLP compliance:
- no
- Test type:
- other: not specified
Test material
- Reference substance name:
- tert-butyl nitrite
- EC Number:
- 208-757-0
- EC Name:
- tert-butyl nitrite
- Cas Number:
- 540-80-7
- Molecular formula:
- C4H9NO2
- IUPAC Name:
- tert-butyl nitrite
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 308 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: Liver - other changes Blood - methemoglobinemiacarboxyhemoglobin
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 in mice was 308 mg/kg.
- Executive summary:
The oral LD50 in mice was 308 mg/kg.
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