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EC number: 936-560-6 | CAS number: 212070-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-10-15 to 2019-06-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- adopted on 27 July 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- Council Regulation (EC) No 440/2008; May 30th 2008
- GLP compliance:
- no
- Type of method:
- other: thermogravimetry and differential scanning calorimetry
Test material
- Reference substance name:
- 2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide
- Cas Number:
- 212070-45-6
- Molecular formula:
- C36H73NO5
- IUPAC Name:
- 2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- The physical state of the test item at 20 °C and 101.3 kPa is a white, crystalline solid. All analyses included in this report have been performed with a batch, which passed the quality control measurements without any irregularity previously. All specifications were met. A purity of 93.5 % was measured.
Results and discussion
Boiling point
- Key result
- Decomposition:
- yes
- Decomp. temp.:
- > 230 °C
- Remarks on result:
- other: The recorded weight loss above 270.6 °C may indicate a beginning evaporation (boiling). Based on visual inspection and the DSC test, where the test item showed a significant change of the melting behaviour, a product decomposition is more likely.
Any other information on results incl. tables
Results
Capillary method
In the melting point system the test item started to become liquid at 128 °C and appeared as a
clear colourless liquid at 149 °C. Starting at a temperature of 250 °C the colour of the specimen
changed from white to dark yellow.
DSC/TGA
As preliminary test a DSC and a TGA run were performed.
Evaluation
In the TGA test, a sample of the test item was heated from 30 °C to 600 °C in an inert gas
atmosphere (N2). The main drop was detected beginning at 270.6 °C (onset). Up to 467 °C a total
weight loss of 99.75 % was recorded.
Within the first heating period of the preliminary DSC test, three endothermic signals were
recorded over a temperature range of approximately 62 °C … 154 °C without a significant weight
loss (0.1 %) presumably representing melting or transition processes from various crystal forms
which corresponds to the visual observation where a clear liquid was observed at 149 °C.
Starting at 216.2 °C (estimated onset) a broad endothermic signal was recorded up to 467 °C
matching the temperature range of the total weight loss record (99.75 %). The endothermic
provided two maxima 246.4 °C and 312.1 °C
Applicant's summary and conclusion
- Conclusions:
- Ceramide VI does not provide a boiling point until disintegration at about 230°C.
- Executive summary:
The boiling point of Ceramide VI was determined according to OECD Guideline 103 (27 July 1995) and EU Method A.2 (30 May 2008) using differential scanning calorimetry, thermogravimetry, NMR analysis and visual inspection. In the TGA test, a sample of the test item was heated from 30 °C to 600 °C in an inert gas atmosphere (N2). Starting at 270 °C a constantly increasing weight loss was recorded. Until 467 °C
the sample lost 99.75 % of its weight. The recorded weight loss above 270.6 °C (estimated onset on TGA) and the corresponding endothermic signal may indicate a beginning evaporation (boiling), however, with respect to the visual observation (colour change of the specimen from white to dark yellow at 250 °C) a decomposition of the test item appears to be more likely. In order to provide evidence for this assumption, a degradation test was performed during which an aliquot of the sample was heated to 230°C (40 °C below the assumed boiling point) for 15 minutes and the remaining residue (98.4 % of the original material) was characterised by NMR spectroscopy. The NMR analysis confirms the beginning decomposition of the product.
Conclusion: no boiling point detected; decomposition above 230 °C (1010 hPa).
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