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EC number: 265-367-3 | CAS number: 65072-36-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 January - 15 May 2019.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 13 April 2004.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Lithium 2-aminobenzothiazole-6-sulphonate
- EC Number:
- 265-367-3
- EC Name:
- Lithium 2-aminobenzothiazole-6-sulphonate
- Cas Number:
- 65072-36-8
- Molecular formula:
- C7H6N2O3S2.Li
- IUPAC Name:
- lithium 2-amino-1,3-benzothiazole-6-sulfonate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Bulk Density (g/ml): 0.39
- Particle size distribution (μm): 19.6
- Water solubility: 20%
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: IR2510181
- Expiration date of the lot/batch: 25 October 2019
- Purity test date: Not specified
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability under test conditions: Not specified
- Solubility and stability of the test substance in the solvent/vehicle: soluble at 100 mg/L in dilution water (ISO medium)
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Dissolved in ISO medium
- Preliminary purification step (if any): Not specified
- Final dilution of a dissolved solid, stock liquid or gel: 100 mg/L (nominal)
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L.
- Analytical measurements were performed at the start and end of the test.
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Age at study initiation (mean and range, SD): < 24 hours.
- Source: István Szent University, 2100 Gödöllő, Páter Károly u. 1, Hungary
- Feeding during test: No.
ACCLIMATION
- Acclimation period: There was no acclimatization because the water used was similar to the culture water.
Study design
- Test type:
- static
- Water media type:
- other: ISO medium, reconstituted water
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- The reconstituted water (ISO medium) had a total hardness of 245 mg/L (as CaCO3).
- Test temperature:
- The water temperature was measured at the start of the experiment and in 24-hour intervals thereafter in each test vessel. The test temperature was in the range of 20.0 – 20.3°C measured in the test vessels.
- pH:
- The pH of the test solution was not adjusted and not varied by more than 1.5 units in any one test. The pH was measured at the start and at the end of the test in each test vessel and was in the range of 7.81 – 7.94.
- Dissolved oxygen:
- The dissolved oxygen concentration was measured in each test vessel at the start and at the end of the test and was in the range of 8.5 – 8.7 mg/L.
- Salinity:
- Not applicable.
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L.
Measured concentration (start of study): 95.6 ± 0.567 mg/L
Measured concentration (end of study): 96.8 ± 1.486 mg/L. - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass beaker
- Type: Closed
- Volume of solution: At least 5 mL test solution/animal.
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): Not applicable. - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Details on results:
- One animal (out of 20) was observed to be immobilised at the end of the 48-hour test period. No treated animals were immobilised after 24 hours, and no control animals were immobilised at any point during the study.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In an acute immobilisation test in Daphnia magna, lithium 2-aminobenzothiazole-6-sulphonate was found to have an EC50 > 100 mg/L.
- Executive summary:
In an OECD guideline study, conducted to GLP, lithium 2-aminobenzothiazole-6-sulphonate was found to have an EC50 > 100 mg/L in Daphnia magna. One treated animal (out of 20) was found to be immobilised at the end of the 48-hour study.
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