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EC number: 443-010-4 | CAS number: 53641-10-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-12-06 to 2000-02-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 443-010-4
- EC Name:
- -
- Cas Number:
- 53641-10-4
- Molecular formula:
- C14H15ClN2O4
- IUPAC Name:
- N-[3-chloro-4-(3-oxobutanamido)phenyl]-3-oxobutanamide
- Test material form:
- solid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Taken from a municipal sewage treatment plant, filtered, and maintained in aerobic condition by aeration until test begin.
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 50 mg/L
- Based on:
- test mat.
Reference substance
- Reference substance:
- other: Sodium acetate
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 56
- Sampling time:
- 28 d
- Details on results:
- Points of degradation plot (test substance):
0 % degradation after 7 d
36 % degradation after 14 d
56 % degradation after 21 d
56 % degradation after 28 d
BOD5 / COD results
- Results with reference substance:
- Points of degradation plot (reference substance):
92 % degradation after 7 d
100 % degradation after 14 d
100 % degradation after 21 d
100 % degradation after 28 d
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- All validity criteria according to the guideline were met
- Interpretation of results:
- not readily biodegradable
- Remarks:
- Pass level of > 70 % biodegradation within a 10-day window was not reached
- Executive summary:
The ready biodegradability in the modified OECD Screening Test was determined with a non-adapted activated sludge for the test item "Cl-DAEP" (batch number: 90003 CCL), over a period of 28 days. The study was conducted from December 07, 1999 to January 04, 2000 according to OECD 301 E in the Dr. U.Noack-Laboratorium für Angewandte Biologie.
The test item was tested in a concentration of 50 mg/L in duplicates, corresponding to a TOC of 0.533 mg C/mg test item and a carbon content of 26.7 mg C/L in the test vessel.
The biodegradation of the test item was followed by the determination of DOC.
In order to check the activity of the study system sodium acetate in a concentration of 130 mg/L was used as functional control. The percentage degradation of the functional control reached the pass level of > 70 % after 1 day. After 14 days, a degradation rate of 1000 % was reached.
In the toxicity control containing both test and reference item, the biodegradation came to 48 % after 14 days. The test item can be assumed to be not inhibitory in the test.
The biodegradation of the test item was compared to a readily degradable functional control and a toxicity control. The test item in the test concentration of 50 mg/L reached the level of 10 % (begin of the biodegradation) after 9 days. In the 10-d-window a mean biodegradation rate of 50 % and after 21 days of 56 % and the plateau was reached. The 70 % level was not passed during the test. After 28 days the biodegradation rate came to 56 %.
The pass level of a biodegradation > 70 % was not reached in a 10-d-window. The test item must be regarded to be "not readily biodegradable" in the 10-d-window.
The validity criteria of the test are fulfilled according to the guideline.
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