Registration Dossier
Registration Dossier
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EC number: 201-612-2 | CAS number: 85-52-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: Literature
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute oral toxicity of 2-benzoylbenzoic acid
- Author:
- Not specified
- Year:
- 1 971
- Bibliographic source:
- Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(11), Pg. 52, 1971.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-benzoylbenzoic acid
- EC Number:
- 201-612-2
- EC Name:
- 2-benzoylbenzoic acid
- Cas Number:
- 85-52-9
- Molecular formula:
- C14H10O3
- IUPAC Name:
- 2-benzoylbenzoic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- Several animals tested : rat and mouse
Administration / exposure
- Route of administration:
- other: not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- rat
- Effect level:
- 880 mg/kg bw
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- mouse
- Effect level:
- 4 600 mg/kg bw
- Clinical signs:
- other: muscle weakness
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Gigiena Truda i Professional'nye Zabolevaniya presents a study on acute exposure of rats and mice to 2-benzoylbenzoic acid. This study shows the following resultas :
Oral / LD50 (rat) : 880 mg/kg
Oral / LD50 (mouse) : 4600 mg/kg
Regarding theses results, the substance is classified in the category 4 based on GHS criteria. - Executive summary:
Gigiena Truda i Professional'nye Zabolevaniya presents a study on acute exposure of rats and mice to 2-benzoylbenzoic acid. This study shows the following resultas :
Oral / LD50 (rat) : 880 mg/kg
Oral / LD50 (mouse) : 4600 mg/kg
Regarding theses results, the substance is classified in the category 4 based on GHS criteria.
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