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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18 Sep 2017 - 08 Jan 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry
Specific details on test material used for the study:
Decomposition temp.: 150°C
Key result
Temp.:
20 °C
Vapour pressure:
0.036 Pa
Key result
Temp.:
25 °C
Vapour pressure:
0.055 Pa

Table: Results of the isothermal TGA analysis (test item)

Experiment

Temperature

Weight loss [µg/min]

νT

[g/cm2/h]

log νT

log PT

PT

[Pa]

1(1) 

70

0.793608

9.47x10-5

-4.02

-0.01

0.97

 

80

1.38327

1.65x10-4

-3.78

0.30

2.0

 

90

2.20965

2.64x10-4

-3.50

0.56

3.6

 

100

3.21250

3.83x10-4

-3.42

0.76

5.8

2

70

0.893306

1.07x10-4

-3.97

0.05

1.1

 

80

1.60912

1.92x10-4

-3.72

0.38

2.4

 

90

2.65990

3.14x10-4

-3.50

0.65

4.5

 

100

3.84558

4.59x10-4

-3.34

0.86

7.3

3

70

1.09245

1.30x10-4

-3.88

0.16

1.5

 

80

1.78942

2.14x10-4

-3.67

0.44

2.7

 

90

2.63240

3.18x10-4

-3.50

0.66

4.6

 

100

3.60903

4.31x10-4

-3.37

0.83

6.7

(1) Experiment 1 was not used in calculation.

The vapour pressure regression curve constructed using the data of Experiment 1 and Experiment 2 had a coefficient of correlation of <0.99. Therefore, it was decided to perform a third experiment and to calculate the coefficient of correlation for the Experiment 1/Experiment 2/Experiment 3, Experiment 1/Experiment 2, Experiment 1/Experiment 3 and Experiment 2/Experiment 3. Only the coefficient of correlation for the Experiment 2/Experiment 3 was >0.99. Based on this, the results from Experiment 1 were excluded.

Conclusions:
The vapour pressure of the substance at 20°C was determined to be 3.6E-2 Pa.
The vapour pressure of the substance at 25°C was determined to be 5.5E-2 Pa.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.

The constants specific for the experimental arrangement were determined using a set of 5 reference compounds. A vapour pressure curve for the test item was constructed from duplicate measurements at 70°C, 80°C, 90°C and 100°C. The vapour pressure of the substance at 20°C and 25°C was determined by extrapolation to be 3.6E-2 Pa and 5.5E-2 Pa, resp.

 

Description of key information

The vapour pressure of the substance at 20°C was determined to be 3.6E-2 Pa.

The vapour pressure of the substance at 25°C was determined to be 5.5E-2 Pa.

Key value for chemical safety assessment

Vapour pressure:
0.055 Pa
at the temperature of:
25 °C

Additional information