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EC number: 602-927-1 | CAS number: 123312-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 7 Nov 1991 to 21 Nov 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- May 12, 1981
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- GLP compliance:
- yes
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- 6-methyl-4-[(E)-[(pyridin-3-yl)methylidene]amino]-2,3,4,5-tetrahydro-1,2,4-triazin-3-one
- EC Number:
- 602-927-1
- Cas Number:
- 123312-89-0
- Molecular formula:
- C10H11N5O
- IUPAC Name:
- 6-methyl-4-[(E)-[(pyridin-3-yl)methylidene]amino]-2,3,4,5-tetrahydro-1,2,4-triazin-3-one
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 800 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Any other information on results incl. tables
No mortality was recorded during the study. Clinical signs in both sexes included piloerection, hunched posture, and dyspnea, which cleared by day 4. Body weight gain was in the expected range. Gross necropsy revealed no observable abnormalities. At autopsy, no compound-related deviations from normal morphology were seen. The acute inhalation LC50 in albino rats was determined to be greater than 1800 mg/m³.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the conditions of the study, the acute inhalation LC50 in male and female rats was determined to be greater than 1800 mg/m³.
- Executive summary:
In a GLP compliant acute inhalation toxicity study performed according to OECD guideline 403, groups of 5 male and 5 female Tif: RAI f (SPF) rats were exposed to the test material. Because of the high variability of particle size of technical material as such, it was not possible to generate an aerosol of sufficient concentration and respirable particle size. For the inhalation study the test material had to be milled twice using a jet mill adding 1 % Sipernat 50S, a highly disperse amorphic siliciumoxide. 5 male and 5 female rats (Tif:RAIf (SPF)) were exposed to milled test material for 4 hours (nose only exposure) at the maximum attainable concentration of 1800 mg/m3 air. The main exposure parameters are given in the following Table:
Nominal concentration
2767 mg/m3
Mean exposure concentration determined gravimetrically + standard deviation
1806 ± 103 mg/m3
Mass median aerodynamic diameter
1.5 - 2.9 µm
Particles < 7 μm (% w/w)
79 - 89
Air flow through generator
32 L/min
Mean chamber temperature
22.8 °C
Mean relative humidity
47 %
No mortality was recorded during the study. Clinical signs in both sexes included piloerection, hunched posture, and dyspnea, which cleared by day 4. Body weight gain was in the expected range. Gross necropsy revealed no observable abnormalities. At autopsy, no compound-related deviations from normal morphology were seen.The acute inhalation LC50 in albino rats was determined to be greater than 1800 mg/m³.
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