Registration Dossier
Registration Dossier
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EC number: 246-788-1 | CAS number: 25279-09-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 February 2018 - 05 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.036 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- >= 4.46 - <= 6.18
- Details on results:
- The solubility of test item at pH 4.49 – 6.18 in water is 0.0358 g/L.
- Conclusions:
- The water solubility at 20 ± 0.5 ºC and at pH ranging 4.49 – 6.18 is 0.0358 g/L.
- Executive summary:
The water solubility determination was performed according to OECD Guideline 105 and EU Method A.6 (GLP study). The flask method was used. The test item measurement both in was conducted with a validated GC-FID method. The water solubility at 20 ± 0.5 ºC and at pH ranging 4.49 – 6.18 is 0.0358 g/L.
Reference
Results on preliminary test:
0.1g in x mL of solution |
0.1 |
0.5 |
1 |
2 |
10 |
100 |
> 100 |
Soluble (+/-) |
- |
- |
- |
- |
- |
- |
+ |
Approximate solubility, g/L |
> 1000 |
1000 to 200 |
200 to 100 |
100 to 50 |
50 to 10 |
10 to 1 |
<1 |
Results of water solubility:
Mixing timeat 30 ºC [days, flasks] |
1 |
2 |
3 |
|||
Samples |
1 |
2 |
3 |
4 |
5 |
6 |
Temperature, ºC |
19.7 |
19.9 |
19.9 |
|||
pH |
6.18 |
4.65 |
4.49 |
|||
Concentration, g/kg |
0.0383 |
0.0351 |
0.0376 |
0.0334 |
0.0360 |
0.0341 |
Average concentration, g/kg |
0.0367 |
0.0355 |
0.0351 |
|||
Average concentration, g/kg |
0.0358 |
|||||
The solubility in water is 0.0358 g/kg. The density of this solution is about 1 kg/L (about water density).
Description of key information
Key study: OECD Guideline 105 and EU Method A.6. GLP study. The water solubility at 20 ± 0.5 ºC and at pH ranging 4.49 – 6.18 is 0.0358 g/L.
Key value for chemical safety assessment
- Water solubility:
- 0.036 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
