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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1988
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals
Author:
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K
Year:
1988
Bibliographic source:
Environ Mol Mutagen. 1988;11 Suppl 12:1-157

Materials and methods

Test guideline
Guideline:
other: Information not available from the abstract
GLP compliance:
not specified
Remarks:
Information not available from the abstract
Type of assay:
other: Salmonella mutagenicity test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Method

Species / strain
Species / strain / cell type:
other: Salmonella typhimurium
Details on test system and experimental conditions:
A preincubation protocol was used. All tests were performed in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters.

Results and discussion

Test results
Key result
Species / strain:
other: Salmonella typhimurium
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Result of Salmonella mutagenicity test on tetradecanoic acid : negative.