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Diss Factsheets
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EC number: 482-130-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 and 08 June 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The work described was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).
- Type of method:
- HPLC estimation method
- Media:
- sewage sludge
- Radiolabelling:
- no
- Test temperature:
- Column temperature = 40.0 ºC
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus:
- Type: Agilent Technologies 1100, incorporating autosampler and workstation
- Type, material and dimension of analytical (guard) column: Genesis CN 120Å (250 x 4.6 mm id)
- Detection system: Refractive index
MOBILE PHASES
- Type: tetrahydrofuran:water (55:45 v/v)
- Experiments with additives carried out on separate columns: no
- pH: 7.0, adjusted using 0.1 m sodium hydroxide
- Solutes for dissolving test and reference substances: tetrahydrofuran
DETERMINATION OF DEAD TIME
- Method: by means of homologous series / by inert substances which are not retained by the column
The dead time was determined by measuring the retention time of formamide
REFERENCE SUBSTANCES
- Identity: Acetanilide, Phenol, Atrazine, Isoproturon, Triadimenol, Linuron, Naphthalene, Endosulfan-diol, Fenthion, -Endosulfan, Phenanthrene , Diclofop-methyl and DDT
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 0.5070 g
- Quantity of reference substances:
- Intervals of calibration:
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k': >2.22
- Calculation of retention times: >9.5
- Determination of the log Koc value: >5.63 - Type:
- Koc
- Value:
- > 427
- Type:
- log Koc
- Value:
- > 5.63
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
- Details of fitted regression line (log k' vs. log Koc):
- Graph of regression line attached
- Average retention data for test substance: - Validity criteria fulfilled:
- yes
- Conclusions:
- - adsorption coefficient (Koc): >4.27 x 105, log10 Koc >5.63
- Executive summary:
The determination was carried out for 'Paraffin waxes (Fischer-Tropsch), full range, C15-50 - branched and linear' using the HPLC screening method, Method C19 of Commission Directive 2001/59/EC (which constitutes Annex V of Council Directive 67/548/EEC).
The adsorption coefficient (Koc) of the test material has been determined to be >4.27 x 105, log10 Koc >5.63.
Reference
A calibration curve was created using the following results as reference standards:
Dead Time |
Retention Time (mins) |
Mean Retention Time (mins) |
|
Injection 1 |
Injection 2 |
||
Formamide |
2.947 |
2.949 |
2.948 |
Standard |
Retention Time (mins) |
Mean Retention Time (mins) |
Capacity Factor (k) |
Log10k |
Log10 Koc |
|
Injection 1 |
Injection 2 |
|||||
Acetanilide |
3.754 |
3.753 |
3.754 |
0.237 |
-0.563 |
1.25 |
Phenol |
4.215 |
4.218 |
4.217 |
0.430 |
-0.366 |
1.32 |
Atrazine |
4.612 |
4.616 |
4.614 |
0.565 |
-0.248 |
1.81 |
Isoproturon |
4.198 |
4.199 |
4.199 |
0.424 |
-0.372 |
1.86 |
Triadimenol |
4.694 |
4.690 |
4.692 |
0.592 |
-0.228 |
2.40 |
Linuron |
4.635 |
4.645 |
4.640 |
0.574 |
-0.241 |
2.59 |
Naphthalene |
5.263 |
5.263 |
5.263 |
0.785 |
-0.105 |
2.75 |
Endosulfan-diol |
4.981 |
4.985 |
4.983 |
0.690 |
-0.161 |
3.02 |
Fenthion |
5.537 |
5.542 |
5.540 |
0.879 |
-5.60 x 10-2 |
3.31 |
a-Endosulfan |
6.948 |
6.947 |
6.948 |
1.36 |
0.132 |
4.09 |
Phenanthrene |
5.604 |
5.601 |
5.603 |
0.900 |
-4.55 x 10-2 |
4.09 |
Diclofop-methyl |
6.325 |
6.322 |
6.324 |
1.15 |
5.88 x 10-2 |
4.20 |
DDT |
7.954 |
7.946 |
7.950 |
1.70 |
0.230 |
5.63 |
The retention times, capacity factors and log10Kocvalues determined for the sample are shown in the following table:
Injection |
Retention Time (mins) |
Capacity Factor (k) |
Log10k |
Log10Koc |
1 |
>9.5 |
>2.22 |
>0.347 |
>5.63 |
2 |
>9.5 |
>2.22 |
>0.347 |
>5.63 |
Mean log10Koc: >5.63
Adsorption coefficient: >4.27 x 105
Description of key information
adsorption coefficient (Koc) of the test material: >4.27E5, log10 Koc >5.63
Key value for chemical safety assessment
- Koc at 20 °C:
- 5.63
Additional information
The determination was carried out using the HPLC screening method, Method C19 of Commission Directive 200l/59/EC (which constitutes Annex V of Council Directive 67/548/EEC).
The adsorption coefficient (Koc) of the test material has been determined to be >4.27 x 105, log10 Koc >5.63
The test material was known to primarily be a complex mixture of alkanes. As the test material eluted after the mobile phase had been adjusted to 100% solvent, all components were deemed to be greater than that of the highest calibration standard.
EUSES 2.1.2 includes QSAR equations for the prediction of the adsorption coefficient Koc from Kow. The appropriate equation is for the ‘hydrophobics’ group, which is:
log Koc = 0.10 + 0.81log Kow
Koc for each block is calculated from the weighted average Kow for the block, given in Table 1.xxx of the Chemical Safety Report and in the overall Physical and chemical properties endpoint summary in IUCLID.
[LogKoc: 0.751]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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