Phenol, 4,4′-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane and N1,N1-diethyl-1,3-propanediamine

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

31 October 2017 - 23 March 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

2016

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

DEPDA adduct

Cas Number:

123739-10-6

IUPAC Name:

DEPDA adduct

Test material form:

solid

Details on test material:

- Physical appearance: dark amber solid
- Storage conditions: at room temperature

Results and discussion

Water solubility

Key result

Water solubility:

< 10 mg/L

Conc. based on:

test mat. (dissolved fraction)

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

>= 6.9 - <= 7.7

Details on results:

The results for the samples at loading rates 100, 1000, 10000 mg/L taken after stirring for 24, 48 and 72 hours are shown in the table below.
The result of the two times filtered sample shows that dissolved test item is not adsorbed to the filter.
The 24-, 48- and 72- hour measurements showed a large spread and it is considered not possible to obtain more accurate results.

Any other information on results incl. tables

      Water Solubility of the Test Item

Loading rate   mg/L	Stirring time [hours]	Absorbance [AU]	Absorbance Corrected(d) [AU]	Analyzed concentration [g/L]	pH
0	72	0.0058a
0	72	0.0065a
0	72	0.0048a
100	24	0.127	0.121	0.00326	7.4
100	48	0.186	0.180	0.00490	7.7
100	72	0.0566	0.051	0.00131	7.6
1000	24	0.0923	0.0866	0.00230	6.9
1000	48	0.118	0.113	0.00302	7.3
1000	72	0.404	0.399	0.0109	7.4
10000	24	0.520	0.514	0.0141	7.4
10000	48	0.760	0.755	0.0208	7.6
10000	72	1.50	1.50	0.041b	7.1
10000	72	1.48	1.48c	0.041b	7.3

a)Mean absorbance of the blank (n=3) is 0.0057 au.

b)Estimated value calculated by extrapolation of the calibration curve.

^c) Absorbance of the samples is corrected for the mean of the blank.

^d) Absorbance of the sample filtrated twice.

The concentration measured increased with the loading rate. The maximum concentration of dissolved test item measured in the aqueous phase was 0.041 g/L after 72 hours stirring time at 20°C at a loading rate of 10000 mg/L. Based on the observation of undissolved material in the nominal 10 mg/L solution used in the preliminary test, it was concluded that the water solubility of the test item is < 10 mg/L.

Applicant's summary and conclusion

Conclusions:

The water solubility of the substance at 20°C was determined to be <10 mg/L.

Executive summary:

The water solubility of the substance was determined using the flask method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840. Quantification was performed by UV. The pH of the aqueous samples was 6.9 - 7.6. From the measurements obtained after 24, 48 and 72 hours at concentrations of 100, 1000 and 10000 mg/L, the water solubility at 20°C was determined to be <= 41 mg/l. Based on visual observation of a water mixture at 10 mg/L nominal (preliminary test), the water solubility was concluded to be < 10 mg/L.