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Diss Factsheets
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EC number: 208-932-1 | CAS number: 547-66-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Oxalic acid
- EC Number:
- 205-634-3
- EC Name:
- Oxalic acid
- Cas Number:
- 144-62-7
- Molecular formula:
- C2H2O4
- IUPAC Name:
- oxalic acid
- Details on test material:
- TEST SUBSTANCE
The test substance consists of a chemical compound.
Product OXALIC ACID DI-HYDRATE
Components Oxalic Acid
Stability 6 months
Formula (COOH)2 2H2O
CAS N° 6153-56-6
TESTED SAMPLE
The test substance consisted of a fine white crystal.
Batch MAR 10-10
Manufacturing date March 2010
Expiry date September 2010
Water solubility 10g/100 ml (water at 20°C)
CoA See Addendum N,1
Receiving EUITVI-7606
Date March 9th, 2010
#ID 10.322-S
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Controls:
- not required
- Duration of treatment / exposure:
- Skin preparation:
4 hours before the beginning of the test an area of approximately 240 cm2 has been shaved off from the
back and hips of the animals. An area of about 6 cm2 was used for the application of the assay sample.
Application:
500 mg of the test substance have been applied on the animal’s skin, after humidification with
physiological solution, with a square gauze (2.5 cm x 2.5 cm) and fixed with an elastic bandaging.
Removal of the patches:
The patches have been removed 4 hours after the application.
The exceeding substance has then been cleansed off from skin using a pad soaked with physiological
solution. - Observation period:
- OBSERVATIONS
The general conditions of the animals have been daily verified. Skin reactions have been evaluated one
hour after removal of the patches.
The evaluation has been repeated 24, 48 and 72 hours after the application. - Number of animals:
- Three rabbits have been used to perform the test.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 60 minutes
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 60 min
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 0
- Other effects:
- not other effect
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- On the basis of the results, interpreted according to Official Journal of the European Union
2001/59/EC dated August 6th, 2001 and OECD n° 404 April 24th 2002, the test substance “OXALIC
ACID DI-HYDRATE” must be considered NOT IRRITANT for the skin. - Executive summary:
A GLP Laboratory test has been conducted following the OECD Guideline TG 404 for Skin irritation.
On the basis of the results, interpreted according to Regulation CE 1272/2008, the test substance “OXALIC ACID DI-HYDRATE” must be considered NOT IRRITANT for the skin.
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