Registration Dossier
Registration Dossier
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EC number: 208-831-2 | CAS number: 542-85-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Ethyl isothiocyanate
- EC Number:
- 208-831-2
- EC Name:
- Ethyl isothiocyanate
- Cas Number:
- 542-85-8
- Molecular formula:
- C3H5NS
- IUPAC Name:
- ethyl isothiocyanate
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- chicken
Test system
- Vehicle:
- physiological saline
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 30µl
- Duration of treatment / exposure:
- 10sec
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Run / experiment:
- maximal mean
- Value:
- 2.3
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation parameter:
- fluorescein retention score
- Run / experiment:
- mean
- Value:
- 3
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation parameter:
- percent corneal swelling
- Run / experiment:
- maximal mean
- Value:
- 15
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The eye irritation potential is evaluated according OECD438 test method. In the test conditions, the test substance is not considered as irritating for eye.
- Executive summary:
The eye irritation potential is evaluated according OECD438 test method. In the test conditions, the test substance is not considered as irritating for eye.
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