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Diss Factsheets
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EC number: 288-309-9 | CAS number: 85711-49-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The read-across substance SALATRIM 23CA lot A014 did not produce chromosomal aberrations, indicating a lack of clastogenic potential. This SALATRIM fat failed to produce evidence of mutagenic potential in a mammalian cell line, in agreement with its lack of mutagenicity in bacteria. No evidence of DNA damage was detected with this fat when assessed by unscheduled DNA synthesis.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
The in vitro studies were extended to an in vivo assay measuring the ability of two additional SALATRIM fats to produce micronucleated polychromatic erythrocytes in bone marrow. This in vivo study is significant because the two SALATRIM fats were fed to rats at high doses (10% of the diet) for a prolonged period (13 weeks). This study is also significant because all mechanisms of digestion, absorption, metabolism, distribution, and excretion were operational in the intact animal. Micronucleated polychromatic erythrocytes did not differ between the SALATRIM fats and the corn oil control, and all of the data were within the range of historical control data for this assay. Therefore, the data from the in vivo genetic toxicology assay confirm the data from the in vitro genetic toxicology assays.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
These studies were done to test the hypothesis, that upon structure/activity relationships and review of the scientific literature, the members of the read-across substances the SALATRIM family of structured triacylglycerols should have no capability of interacting with mammalian cell DNA to produce genetic changes. The studies of SALATRIM fats using bacterial test systems, in vitro mammalian cell cultures and an in vivo rat study support the conclusion that SALATRIM fats should possess no genotoxic potential.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.