Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Aug 2018 to 25 Aug 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 2.47 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other: calculated mean solubility
- Water solubility:
- 2.45 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 25 mg/L
- Temp.:
- 20 °C
- pH:
- 7
- Water solubility:
- 2.49 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 12.5 mg/L
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- The solubility of Amberonne SHK in milli-Q water at a flow rate of 25 mL/hour and 12.5 mL/hour was found to be 2.45 mg/L and 2.49 mg/L, respectively. The calculated mean concentration was determined to be 2.47 mg/L at
20°C. - Conclusions:
- Method validation parameters evaluated for the test item meet the acceptance criteria. The results obtained are within the specified limits. Thus, this method is suitable for the analysis of the test item. The solubility of the test item in milli-Q water is found to be 2.47 mg/L at 20°C with pH 7.0.
- Executive summary:
The water solubility of the test item was determined as per OECD guideline for the testing of chemicals, No. 105. The water solubility of the test item was found to be less than 10^-2 g/L in milli-Q water during the preliminary test. For further confirmation the definitive test was performed in milli-Q water under laboratory conditions at 20°C by the column elution method. The samples were analyzed for test item concentration by gas chromatography. The solubility of the test item in milli-Q water at a flow rate of 25 mL/hour and 12.5 mL/hour was found to be 2.45 mg/L and 2.49 mg/L, respectively. The calculated mean concentration was determined to be 2.47 mg/L at 20°C. Method validation parameters evaluated for the test item meet the acceptance criteria. The results obtained are within the specified limits. Thus, this method is suitable for the analysis of the test item. The solubility of the test item in milli-Q water is found to be 2.47 mg/L at 20°C with pH 7.0.
Reference
Description of key information
The water solubility was tested according to the OECD 105 guideline, and it was determined to be 2.47 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 2.47 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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