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EC number: 203-894-2 | CAS number: 111-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-03-02 to 1982-04-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restrictions because the study closely followed OECD 402 guidelines and was GLP compliant.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Study conducted before guideline introduced
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Study conducted before guideline introduced
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 111-66-0
- Molecular formula:
- C8H16
- Details on test material:
- - Name of test material (as cited in study report): Neodene 8 alpha olefin
- Substance type: C8 alpha olefin
- Physical state: Liquid
- Lot/batch No.: Sample number 618A
- Stability under test conditions: Stated that stability was confirmed.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ray Nichols Rabbitry, Lumberton, Texas
- Weight at study initiation: Approximately 3000 grams
- Acclimation period: 21 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.4-21.1°C
- Humidity (%): 25-60%
- Photoperiod (hrs dark / hrs light): 12 hours dark/12 hours light
IN-LIFE DATES: From: 1982-03-02 To: 1982-04-06
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 4 x 4 inch
Type of wrap if used: aluminium foil taped in place then overwrapped with an elastic Ace bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): With a moist towel
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 mL/kg
- Constant volume or concentration used: Yes - Duration of exposure:
- 24 hours
- Doses:
- 2 mL/kg
- No. of animals per sex per dose:
- Eight animals/sex/dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed at 1, 2, 4, 6, and 24 hours after exposure, then twice daily for 14 days. Animals were weighed at study initiation, 7 days, and 14 days.
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, body weight, and skin irritation - Statistics:
- An independent T-test with p<0.05 was used on body weight data.
Results and discussion
- Preliminary study:
- None performed.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 mL/kg bw
- Remarks on result:
- other: Equivalent to > 1430 mg/kg
- Mortality:
- No animals died over the 14 day observation period.
- Clinical signs:
- other: There were no clinical signs of toxicity related to treatment.
- Gross pathology:
- The only findings at necropsy were related to the treatment site and included white crust material on the skin and fur (considered dried test material), alopecia, abrasions, erosion, and in one animal cutaneous firmness.
- Other findings:
- - Other observations: There was mild to moderate erythema and oedema following the removal of the wrappings at 24 hours. Mild irritation was still present at 14 days. There was no difference in the level of irritation between the intact and abraded skin.
Any other information on results incl. tables
Summary of Skin Irritation (Average and Range) |
||||
|
24 hours |
14 days |
||
|
erythema |
oedema |
erythema |
oedema |
Treated intact skin |
1.6 (0 to 2) |
1.4 (0 to 3) |
0.9 (0 to 2) |
0.4 (0 to 1) |
Control intact skin |
0.1 (0 to 1) |
0.0 |
0.0 |
0.0 |
Treated abraded skin |
0.8 (0 to 2) |
1.4 (1 to 4) |
1.3 (0 to 2) |
0.5 (0 to 1) |
Control abraded skin |
0.0 |
0.4 (0 to 1) |
0.0 |
0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- LD50 is greater than the maximum concentration tested (i.e., 1430 mg/kg) Criteria used for interpretation of results: EU
- Conclusions:
- Acute dermal LD50 was > 2.0 mL/kg.
- Executive summary:
In an acute dermal toxicity study, groups of New Zealand rabbits (8/sex) were dermally exposed to 2 mL/kg of undiluted Neodene 8 alpha olefin (i.e., 1 -octene) to a 4 x 4 inch section for 24 hours. Four of the animals per sex and treatment had their skin abraded prior to treatment. Animals were then observed for 14 days. There was no treatment-related lethality, clinical signs of toxicity, changes in body weight, or necropsy findings. The only notable finding was mild to moderate skin irritation following the removal of the wrappings at 24 hours. Mild skin irritation was still present on day 14. Skin irritation was not effected by abrading the skin. The dermal LD50 was determined to be greater than 2.0 mL/kg in males and females. This study received a Klimisch score of reliable without restrictions because the study closely followed OECD 402 guidelines and was GLP compliant.
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