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EC number: 222-774-0 | CAS number: 3608-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- See executive summary.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- 1-methyl-4-piperidyl diphenylglycolate has to be classified as „Acute toxicity-oral“ in Category 4.
- Executive summary:
Normally a test for the determination of the endpoint „ Acute Toxicity, oral” (e.g. acc. to EU-methods B.1-bis (OECD420) or B.1-tris (OECD423) would be required.
An adaption of the standard testing regime is possible (e. g. by “data waiving”), if the test does not appear scientifically necessary and other information are available.
Data from old, experimental studies are available. The “Acute Toxicity, oral” was tested with a experimental study in 1981 by the “Center for product toxicology of chemical industry Graupa [Zentralstelle für Produktentoxikologie der Chemischen Industrie Graupa]” in a conventional, classic test. This test was in accordance with national standard methods with acceptable restrictions and therefore with a reliability value of 2. This center of product toxicology was the only legal place in the former GDR for such tests (legal-controlled with compliance of international regulations, e.g. principles of the later OECD401).Report Determination of Acute Toxicity, oral of Benzilic acid-N-methylpiperidinyl-(4)-ester (P0-base); [10. 07. 1981]
- Data source:
- Date of report: 10. 07. 1981
- Authors: I. Frosch; K. Stade
- Year: 1981
- Testing laboratory: Zentralstelle für Produktentoxikologie der Chemischen Industrie Graupa
- Company owner: VEB Apogepha Dresden
- Language: German
- Materials and methods
- test guideline: not explicitly stated; classic method in accordance to OECD401
- Test material:batch161179; in-house monography Apogepha (assay > 98 %; purity by TLC with benzylic acid and benzylic acid methyl ester and 1-methyl-4-hydroxy-piperidine nmt. 0.1 %; loss on drying nmt. 1 % etc.); test date unknown;
- Storage: room temperature
- Test animals:
- Species: rat; strain Wistar (VEB Versuchstierproduktion Schönwalde)
- Sex: male/female; average weight male 167 +/- 10 g; female 170 +/-14 g; housing with max. 10 animals in one cage at 22 +/- 2 ° C; food standard pellets formulation R/3 ad libitum; water ad libitum
- Administration/exploration
- Route of administration: oral with gavage; as 20 % solution in 0.5 % aqueous Tylose solution
- Time of administration 1 week; January 1981
- Pretest: 15 female
- Full-test: 30 male and 30 female
- Doses: male: 1250 mg/kg and 1500 mg/kg and 1750 mg/kg
- Doses female: 1000 mg/kg and 1250 mg/kg and 1500 mg/kg
- No. of animals per sex and dose: 10
- Control animals: no
-Evaluation and poisoning symptoms:
after application and after 0.5 h, 2 h, 6 h, 24 h, and 48 h with symptoms, like ataxie, exophthalmos, bloody saliva, cramps; piloerection, Righting-refllex etc.; Evaluation with “probit-regression analysis”Mortality
Dose mg/kg
Sex
No: of animals
No. of died animals after
24 h
48 h
7 d
1000
female
10
2
2
2
1250
female
10
5
5
5
1500
female
10
7
9
9
1250
male
10
3
4
4
1500
male
10
4
4
5
1750
male
10
7
8
9
Effect level, based on test material:
- male 24 h LD50 = 1527 mg/kg (1308-1783 mg/kg)
- female 24 h LD50 = 1273 mg/kg (1104-1468 mg/kg)This old results of the study is reliable with restrictions (Klimisch-code of 2) and therefore certain, consistent and safe to avoid additional animal testing. They can be used for CLP classification and risk assessment.
Conclusion:
1-methyl-4-piperidyl diphenylglycolate “ has to be classified in the Hazard Class „Acute toxicity-oral“ in Category 4 with „H302: Harmful if swallowed”.
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