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Short-term toxicity to aquatic invertebrates

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short-term toxicity to aquatic invertebrates
Type of information:
Adequacy of study:
key study
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Composition 0
no guideline followed
Principles of method if other than guideline:
Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.0
- Water solubility selected: 252.21 mg/L (measured)
- Partition coefficient selected: 2.3 (measured)
Test material information:
Composition 1
Key result
48 h
Dose descriptor:
Effect conc.:
60.49 mg/L
Nominal / measured:
Conc. based on:
test mat.

Description of key information

The estimated 48h-LC50 is 60.49 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
60.49 mg/L

Additional information

For the assessment of the aquatic toxicity of the test substance to daphnia, QSAR results were used. ECOSAR v2.0 was used as the QSAR model and a water solubility of 252.21 mg/L and a partition coefficient of 2.3 was used for the prediction of the aquatic toxicity in daphnia. The results fell within the applicability domain of the QSAR model and subsequently the criteria listed in Annex XI of Regulation (EC) No 1907/2006 chapter 1.3 are considered to be fulfilled. Therefore, other studies on aquatic toxicity in daphnia are not provided.