Registration Dossier
Registration Dossier
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EC number: 287-090-7 | CAS number: 85409-23-0
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 23, 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A test substance was added to the n-octanol at 25ºC and stirred continuously until test substance was dissolved and there was no particles or precipitation. Same process was continued by adding the fixed amount of test substance until there was a visual precipitation noted. When there was a precipitation noted, the process was stopped (at approx. 100 mg/L). A portion of the upper n-octanol layer was centrifuged and analyzed by HPLC-ELSD.
- GLP compliance:
- not specified
- Key result
- Medium:
- n-octanol
- Solubility:
- ca. 93.7 g/L
- Temp.:
- 25 °C
- Test substance stable:
- not determined
- Conclusions:
- Under the study conditions, the n-octanol solubility of the test substance was determined to be 93.7 g/L.
- Executive summary:
A study was conducted to determine the n-octanol solubility of the test substance, C12-14 ADEBAC (activity: 51.13%), according to the HPLC-ELSD Method. Approximately 10 g of the test substance was added in 100 mL n-octanol under constant stirring and constant temperature (25°C). Once the solution turned clear, another 10 g of the sample was added at approximately 2 g interval. Once the solution turned clear, additional 1.5 g of the sample was added. The process showed continual visual precipitation of water. The process was stopped at the approximate 100g/L solubility. A portion of the upper n-octanol layer was centrifuged and analyzed by HPLC-ELSD. Quantitative analysis was performed using external standard calibration. Under the study conditions, the n-octanol solubility of the test substance was determined to be 93.7 g/L (Migliaro, 2018).
Reference
Description of key information
The n-octanol solubility of the test substance was determined and analysed by HPLC-ELSD method (Migliaro, 2018).
Key value for chemical safety assessment
- At the temperature of:
- 25 °C
- Solubility in organic solvents at 20°C:
- 93.7 g/L
Additional information
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