Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

Workers will not be exposed to the substance as only the end-product (solid ink preparation) will be imported into the EU.

For risk assessment purposes, workers will be treated the same as the general population.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
3 000
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
3 000
Modified dose descriptor starting point:
NOAEC

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
3.33 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
300
Modified dose descriptor starting point:
NOAEL
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
3.33 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
300
Modified dose descriptor starting point:
NOAEL

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
3.33 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
300
Modified dose descriptor starting point:
NOAEL
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
3.33 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
300
Modified dose descriptor starting point:
NOAEL

General Population - Hazard for the eyes

Additional information - General Population

Corsair Clear #12 showed no toxicologically adverse effects in any of the conducted studies.

  • Acute oral toxicity (rat): LD50 > 5000 mg/kg
  • Acute dermal toxicity (rat): LD50 > 2000 mg/kg
  • Skin irritation (rabbit): not irritating to the skin
  • Eye irritation (rabbit): not irritating to the eyes
  • Skin sensitisation (mouse local lymph node assay): not sensitising to the skin
  • Subacute oral toxicity (rat): NOAEL >= 1000 mg/kg bw/d
  • Reproduction/developmental toxicity screening (rat): NOAEL >= 1000 mg/kg bw/d
  • Ames test: not mutagenic
  • Chromosome aberration test: not clastogenic
  • Mouse lymphoma test: not mutagenic

DNEL's have been derived from the NOAEL values of 1000 mg/kg bw/d for repeated dose toxicity and reproductive/developmental toxicity. An overall assessment factor of 300 was used and a body weight of 60 kg. The assessment factor is calculated as follows: 4 (allometric scaling) x 2.5 (other interspecies variation) x 10 (intraspecies variation general population) x 3 (exposure duration subacute to sub/semi-chronic) x 1 (route-to-route extrapolation) x 1 (dose-respons). For inhalation exposure an extra factor of 10 is used for extrapolation from the oral to the inhalatory situation (oral absorption factor 10%; inhalatory absorption factor 100%; see toxicokinetic assessment in section 7.1)