Registration Dossier
Registration Dossier
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EC number: 262-774-8 | CAS number: 61417-49-0
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- As the target substance is hydrolytically unstable with hydrolysis half-life less than 1 hr at 30°C, testing is not feasible. According to hydrolysis test results, the hydrolysis products have been identified to be 2-propanol, isostearic acid and titanium dioxide. The physical, toxicological and ecotoxicological properties of the organic parts have been well-investigated. Read-across approach from hydrolysis products are used for assess the target substance.
QSAR modelling is used to calculate vapour of the hydrolysis products. - Qualifier:
- according to guideline
- Guideline:
- other: calculation
- Principles of method if other than guideline:
- Calculation based on MPBPWIN v1.43, Estimation Programs Interface Suite™ for Microsoft® Windows v4.10. US EPA
- GLP compliance:
- no
- Type of method:
- other: QSAR
- Key result
- Test no.:
- #1
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 0 Pa
- Conclusions:
- The vapour pressure of the target substance was 0 Pa at 25°C by calculation.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- 2-propanol is one of the hydrolysis product of the target substance which is expected to have high volatility.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Not specified. Data from collection of handbook.
- GLP compliance:
- not specified
- Type of method:
- other: not specified.
- Key result
- Test no.:
- #1
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 60.2 hPa
- Conclusions:
- THe vapour pressure of 2-propanol is 60.2 hPa at 25°C according to literature.
Referenceopen allclose all
Description of key information
The vapour pressure of the target substance is 0 Pa using QSAR calculation method. As the target substance hydrolyses rapidly to form 2 -propanol and isostearic acid, the physical property of the hydrolysis products are used for read-across. 2 -propanol, the product with high vapour pressure of 60.2 hPa. is used for CSA.
Key value for chemical safety assessment
- Vapour pressure:
- 60.2 hPa
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
