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Diss Factsheets
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EC number: 944-090-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Explosiveness
Administrative data
Link to relevant study record(s)
- Endpoint:
- explosiveness, other
- Type of information:
- other: Expert assessment
- Adequacy of study:
- key study
- Study period:
- January 26, 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An expert assessment for explosive behaviour based on an examination of the molecular structure (e.g. functional groups) and composition of the substance and its components, along with available literature and hazard information
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An expert assessment for explosive behaviour based on an examination of the molecular structure (e.g. functional groups) and composition of the substance and its components, along with available literature and hazard information
- GLP compliance:
- no
- Key result
- Parameter:
- other: Expert assessment
- Remarks:
- Explosiveness
- Remarks on result:
- other: Does not possess chemical functionality associated with explosive properties
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Following an expert assessment based on available literature, hazard information, and experimental data, it has been concluded that the reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) does not have any chemical functionality that is associated with explosive properties. Further testing is not needed according to Column II of REACH Annex VII.
- Executive summary:
The explosiveness of the reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) was determined in an expert assessment based on examination of the molecular structure and composition of the substance using relevant literature and data. Structural motifs in organic material that are associated with explosive potential were identified in Appendix 6 of the UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed. and were used as a basis for review. Section 2.1.4.2 of the CLP regulation (EC 1272/2008) was referred to in order to structure a screening procedure, as well as hazard information for two main constituents of the substance: 6-[(p-tosyl)amino]hexanoic acid and morpholine. Only one of the functional groups listed in Appendix 6 is present in the registration substance, namely C-C unsaturation (acetylenes, acetylides, 1,2-dienes) within the component 6-[(p-tosyl)amino]hexanoic acid, compound with 2-aminoethanol (1:1). However, the only C-C unsaturation present is the di-substituted aromatic ring and it does not carry substituents, such as nitro groups, that are known to give rise to explosive behaviour. As there were no structural motifs associated with explosive behaviour, it is suggested that the reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not predisposed to explosive behaviour and further testing is not necessary (Column II of REACH Annex VII).
Reference
Assessment of the Reaction Mass of Morpholine and 6-[(p-Tosyl)amino]hexanoic Acid, Compound with Morpholine (1:1) for Functionality Typically Associated with Explosive Properties:
Functional Group* | Comments/Conclusions | ||
6-[(p-Tosyl)amino]hexanoic acid, compound with 2-aminoethanol (1:1) | Morpholine | Water | |
C-C unsaturation (acetylenes, acetylides, 1,2-dienes) | The only C-C unsaturation present is the di-substituted aromatic ring; however, it does not carry substituents, such as nitro groups that are known to give rise to explosive behaviour. | Not present | Not present |
C-Metal and N-Metal (Grignard reagents, organo-lithium compounds) | Not present | Not present | Not present |
Contiguous N atoms (azides, aliphatic azo compounds, diazonium salts, hydrazines | Not present | Not present | Not present |
Contiguous O atoms (peroxides, ozonides) | Not present | Not present | Not present |
N-O (hydroxylamines, nitrates, nitro compounds, nitroso compounds, N-oxides) | Not present | Not present | Not present |
N-Halogen (chloramines, fluoroamines) | Not present | Not present | Not present |
O-Halogen (chlorates, perchlorates) | Not present | Not present | Not present |
*Taken from Table A6.1 in Appendix 6 of the UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed.
Description of key information
Following an expert assessment based on available literature, hazard information, and experimental data, it has been concluded that the reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) does not have any chemical functionality that is associated with explosive properties. Further testing is not needed according to Column II of REACH Annex VII.
Key value for chemical safety assessment
- Explosiveness:
- non explosive
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.