Registration Dossier
Registration Dossier
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EC number: 816-307-5 | CAS number: 45738-97-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to QPRF/QMRF documentation for detailed information on model suitability
Data source
Reference
- Reference Type:
- other: Estimation software
- Title:
- Estimation Programs Interface Suite for Microsoft Windows, v4.11
- Author:
- US EPA
- Year:
- 2 012
- Bibliographic source:
- United States Environmental Protection Agency, Washington DC, USA; November 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
- Version / remarks:
- May 2008
- Principles of method if other than guideline:
- QSAR prediction using ECOSAR v1.11.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,7-dihydropurin-6-one;sodium
- Cas Number:
- 45738-97-4
- Molecular formula:
- C5H3N4NaO
- IUPAC Name:
- 3,7-dihydropurin-6-one;sodium
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: White powder
- Purity / Composition: 98%
- Test item storage: Room temperature
Constituent 1
- Specific details on test material used for the study:
- SMILES : O([Na])c1ncnc2ncnc12
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- other: Green Algae (genus species not reported)
Study design
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 1.18 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR
- Remarks:
- Imidazoles
- Basis for effect:
- other: predicted
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 122.87 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR
- Remarks:
- Amines
- Basis for effect:
- not specified
- Details on results:
- see QPRF/QMRF
Applicant's summary and conclusion
- Conclusions:
- Green algae 96-hr EC50: 1.18 mg/L (Imidazoles)
Green Algae 96-hr EC50: 122.87 mg/L (Amines) - Executive summary:
Green algae 96-hr EC50: 1.18 mg/L (Imidazoles)
Green Algae 96-hr EC50: 122.87 mg/L (Amines)
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