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EC number: 234-721-9 | CAS number: 12027-61-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1973
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- see free text field principles of methode
- Principles of method if other than guideline:
- Solutions for dosing. Unless otherwise specified, 113SnS04 (about 0.1 μCi/mg tin),
prepared as previously described (Hiles, 1973), was used in preparing the dosing solutions
containing 2 mg of tin/ml: (1) 113SnF2 in 0.002 N H2S04 at pH 3.7; (2) 1 13SnF4
in 0.02 N H2S04 at pH 2. 7; (3) 113Sn(II) citrate with 2 mol of citric acid/mo! of tin at
pH 5. 7; ( 4) 113Sn(IV) citrate with 4 mo! of citric acid/mo! of tin at pH 5. 7; and
(5) 1 13Sn2P201 in 0.002 N H2S04 at pH 5.6.
113Sn(II) solutions were prepared by mixing 113
SnS04 into a solution containing
NaF, citric acid or Na4P207 and then adjusting the pH (Hiles, 1973). By titration with
standard Kl04 solution to the potentiometric end point, it was shown that the tin in
these solutions was>98 % as Sn(II) and remained as such for at least 1 hr when prepared
using air-free reagents and held under an atmosphere of N2• Syringes used for dosing
Sn(II) solutions were filled and held under an atmosphere of N2 until immediately
prior to dosing. 113Sn(IV) solutions were prepared by titrating the proper 113Sn(II)
solution with H202 to the potentiometric end point before adjusting to final pH.
113Sn determinations. At necropsy, the entire organ or tissue sample was placed in a
scintillation vial. Blood samples were separated into clot and serum and the clot was
washed twice with water before counting. The bone sample was cleaned of connective
tissues before counting and after counting, dried at l l 0°C and then weighed. The carcass
was frozen in dry ice, ground to a powder, blended and samples taken for counting.Feces
were placed in scintillation vials as collected, while gastrointestinal washes were homogenized
and then aliquoted. Samples of the dosing solution were taken for counting in
each experiment. The amount of 113Sn was determined 48 hr after taking the samples
using a Packard Tandem Autogamma Counter Model 5024 and counting the activity
of the daughter element of 113Sn(113ln) at 392 Ke V. Statistical comparison of the results
was made by the method of least significant difference using Student's t test. - GLP compliance:
- no
Test material
- Reference substance name:
- Stannous citrate
- Cas Number:
- 6493-69-2
- Molecular formula:
- C12H14O14Sn
- IUPAC Name:
- Stannous citrate
- Test material form:
- solid: crystalline
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- other: Charles River
- Sex:
- female
Administration / exposure
- Route of administration:
- other: po, iv
- Vehicle:
- not specified
- Details on exposure:
- seee attached report
- Duration and frequency of treatment / exposure:
- 1d - 28d
Doses / concentrationsopen allclose all
- Dose / conc.:
- 20 other: ng Sn / kg
- Remarks:
- iv 1 time
- Dose / conc.:
- 2 other: mg Sn / kg
- Remarks:
- iv
- Dose / conc.:
- 20 other: mg /Sb / kg
- Remarks:
- for 28d study
- Control animals:
- no
Results and discussion
Main ADME resultsopen allclose all
- Type:
- excretion
- Results:
- Feces and GI wash - 98.00 ± 2.1 %
- Type:
- excretion
- Results:
- Urine 0.90 ± 0.23 %
- Type:
- distribution
- Results:
- Liver 0.07 ± 0.02 %
- Type:
- distribution
- Results:
- Kidneys 0.05 ± 0.02 %
- Type:
- distribution
- Results:
- Pancreas <0.004 &
- Type:
- other: Recovery
- Results:
- Recovery 99.02 ± 2.3
- Type:
- distribution
- Results:
- Bone (femur) 0.09 ± 0.04
- Type:
- distribution
- Results:
- Lymph nodes <0.004
- Type:
- distribution
- Results:
- Blood clot 0.01 ± 0.00 %
- Type:
- distribution
- Results:
- Leg muscle <0.004 %
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- see attached report
- Details on distribution in tissues:
- see adme results
Transfer into organsopen allclose all
- Key result
- Test no.:
- #1
- Transfer type:
- secretion via gastric mucosa
- Observation:
- distinct transfer
- Key result
- Test no.:
- #2
- Transfer type:
- other: urine
- Observation:
- slight transfer
Toxicokinetic parameters
- Key result
- Test no.:
- #1
- Toxicokinetic parameters:
- half-life 1st:
- Remarks:
- 23 d
Metabolite characterisation studies
- Metabolites identified:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The majority of the stannic citrate given to rats is execreted via fectes. The half life time of absorped Sn(IV) was determined to be 23 d
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