Registration Dossier
Registration Dossier
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EC number: 227-193-6 | CAS number: 5704-04-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached QPRF and QMRF documents.
Data source
Referenceopen allclose all
- Reference Type:
- other: computer model
- Title:
- ECOSAR v1.11
- Author:
- US Environmental Protection Agency's Office of Chemical Safety and Pollution Prevention
- Year:
- 2 017
- Bibliographic source:
- https://www.epa.gov/tsca-screening-tools/ecological-structure-activity-relationships-ecosar-predictive-model
- Reference Type:
- other: Estimation software
- Title:
- Estimation Programs Interface Suite for Microsoft Windows, v4.11
- Author:
- US EPA
- Year:
- 2 012
- Bibliographic source:
- United States Environmental Protection Agency, Washington DC, USA; November 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
- Version / remarks:
- May 2008
- Principles of method if other than guideline:
- QSAR prediction using ECOSAR v1.11.
- GLP compliance:
- no
Test material
- Reference substance name:
- N-(tri(hydroxymethyl)methyl)glycine
- EC Number:
- 227-193-6
- EC Name:
- N-(tri(hydroxymethyl)methyl)glycine
- Cas Number:
- 5704-04-1
- Molecular formula:
- C6H13NO5
- IUPAC Name:
- 2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SMILES : O=C(O)CNC(CO)(CO)CO
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- other: Green Algae (genus species not reported)
Study design
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 145 000 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR
- Remarks:
- Neutral Organic SAR (Baseline Toxicity)
- Basis for effect:
- other: predicted
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 92 560.04 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR
- Remarks:
- Aliphatic Amines-acid
- Basis for effect:
- not specified
- Details on results:
- see QPRF/QMRF
Applicant's summary and conclusion
- Conclusions:
- Green algae 96-hr EC50: 1.45e+005 mg/L (Neutral Organic SAR (Baseline toxicity)
Green Algae 96-hr EC50: 92560.039 mg/L (Aliphatic Amines-acid) - Executive summary:
Green algae 96-hr EC50 1.45e+005 mg/L (Neutral Organic SAR (Baseline toxocity)
Green Algae 96-hr EC50: 92560.039 mg/L (Aliphatic Amines-acid)
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