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EC number: 825-518-1 | CAS number: 2060541-47-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15-19 June 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Good quality study under GLP, however no chemical analyses. Therefore concentrations nominal.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- no chemical analysis
- Principles of method if other than guideline:
- no chemical analyses
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Details on sampling:
- no chemical analyses
- Details on test solutions:
- Direct dispersion in water. 2.0 g of test material was dispersed in water and the volume adjusted to 1 litre to give a 2.0 g/L stock solution . 10, 18, 32, 56 and 100 mL aliquots of this stock solution were each separately dispersed in dechlorinated tap water and the volume adjusted to 20 litres to give
the test series. 1.0, 1.8, 3.2, 5.6 and 10 mg/L. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Rainbow trout (Oncorhynchus mykiss)
Source: Parkwood trout farm, Wigmore, kent, United Kingdom.
The stock of fish was held since 16 April 1992 and was acclimatised to test conditions from 8 -15 June 1992.
The stock fish were maintained in a glass fibre tank with a single-pass water renewal system. The light was controlled to give a 16h light and 8h
darkness cycle. Fish were fed dailey with commercial trout pellets, but feeding was discontinued 24h prior to the test.
Mean standard length = 4.3 cm (SD = 0.4 cm), mean weight = 1.00 g (SD = 0.29 g), no data on age of fish. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- no
- Hardness:
- Approximately 50 mg/L as CaCO3
- Test temperature:
- 14 ºC
- pH:
- 7.2-7.3
- Dissolved oxygen:
- 10.0-10.1 mgO2/L
- Salinity:
- no data
- Nominal and measured concentrations:
- nominal concentrations: 1.0, 1.8, 3.2, 5.6 and 10 mg/L (30% a.i.)
Concentration based on active ingredient: 0.3, 0.54, 0.96, 1.68 and 3 mg a.i./L - Details on test conditions:
- The test material was suspected to absorb to glassware and so saturation of the absorption sites was achieved by soaking the test vessels overnight prior to the start of the test with the test solutions. At 0 hours the test vessels were emptied, rinsed with the solution to be tested and then refilled
with the fresh test solution.
There was a dailey renewal of test media to ensure stability of the test concentrations.
The lightning was controlled at 16h light- 8 h darkness cycle.
Test vessels: Glass aquaria holding 20L of test media. 5 test concentration in duplicate, plus 1 control (20 animals per test concentration).
Fish were placed at random in prepared test media, loading 0.50 g bodyweight/L.
Aeration via narrow bore glass tubes.
Criteria of death: absence of (i) respiratory movement and (ii) response to a physical stimulation. - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.39 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- 30% active ingredient
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL (0.3-0.54 mg/L)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL (1.0-1.8 mg/L)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Results with reference substance (positive control):
- no reference substance
- Reported statistics and error estimates:
- 96 h LC50 1.3 mg/L 95% CL (1.0-1.8 mg/L)
- Sublethal observations / clinical signs:
Nominal concentration (mg/L)
Cumulative Mortality
(initial population: 10)
6 h
24h
48h
72h
96 h
Control
0
0
0
0
0
1.0
0
0
0
0
0
1.8
0
0
10
10
10
3.2
0
9
10
10
10
5.6
8
10
10
10
10
10
10
10
10
10
10
- Validity criteria fulfilled:
- yes
- Conclusions:
- Good quality study, however no chemical analyses therefore concentrations nominal.
- Executive summary:
The acute toxicity of Tallowamphotriaminopolycarboxyglycinate to rainbow trout (Oncorhynchus mykiss) was tested according to OECD guideline 203 (1984) and "Fish, Acute Toxicity Test" referenced as Method C.l of Commission Directive 84/449/EEC (which constitutes Annex V of Council Directive 67/548/EEC).
The test concentrations were 1, 1.8, 3.2, 5.6 and 10 mg/L test substance (30% active ingredient) and the test solution were refreshed daily.
Highest test concentration resulting in 0% mortality = 1.0 mg/L (0.30 mg a.i./L)
Lowest test concentration resulting in 100% mortality = 1.8 mg/L (0.54 mg a.i./L)
"No Observed Effect Concentration" (NOEC) = 1.0 mg/L (0.30 mg a.i./L)
The "No Observed Effect Concentration" is based upon zero mortalities and the absence of any behavioural reactions to exposure at this concentration.
Reference
Description of key information
Acute fish studies are available for Sodium tallowamphopolycarboxy glycinate (Sewell 1993), Tallowamphotriamino polycarboxy glycinate (Sewell 1992) and tallowamphopolycarboxy glycinate (Douglos 1988). The three substances are considered to be identical substances under environmental conditions and consequently for all three substances similar LC50 values were observed of respectively, 0.42 mg a.i./L (95% 0.32 -0.56), 0.39 mg a.i./L and 0.52 mg a.i./L.
The lowest LC50 is used here as a worst-case as also the geometric mean may be used in case of equal quality.
These results are in good agreement with the results observed for a strongly related substance Sodium oleylamphopolycarboxy glycinate (CAS no.: 2060541 -49 -1) for which two acute fish studies are available and which hamper from the same short commings i.e. lack the quantification of the test substance during the test. The first study with the Sodium oleylamphopolycarboxy glycinate from Sewell & Grant-Salmon(1993) resulted in a 96h LC50 for rainbow trout of 1.3 mg a.i./L based on nominal test concentrations. The second study from Handley and Mead (1992) resulted in a 96h LC50 for rainbow trout of 0.72 mg a.i./L based on nominal test concentrations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.39 mg/L
Additional information
Acute fish studies are available for Sodium tallowamphopolycarboxy glycinate (Sewell 1993), Tallowamphotriamino polycarboxy glycinate (Sewell 1992) and tallowamphopolycarboxy glycinate (Douglos 1988). All three studies lack the quantification of the test substance during the test. When these studies were performed no suitable sensitive analytical method was available for the quantification of this type of test substances. The substance is however very soluble (640 g/L at pH 6.4) and is therefore expected to be completely bioavailable during the acute fish and daphnia ecotoxicity tests. During algae tests however a decrease of the dissolved test substance concentration is anticipated due to some sorption of the substance to the large surface area of the algae. Where for the acute fish and daphnia the use of nominal concentrations is considered appropriate a geometric mean should be applied to the algae test results.
The lowest LC50 of 0.39 mg/L based on nominal active ingredient concentration is used here as a worst-case.
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