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Diss Factsheets
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EC number: 217-683-8 | CAS number: 1929-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.12.2006 - 14.12.2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Mecoprop
- EC Number:
- 230-386-8
- EC Name:
- Mecoprop
- Cas Number:
- 7085-19-0
- Molecular formula:
- C10H11ClO3
- IUPAC Name:
- 2-(4-chloro-2-methylphenoxy)propanoic acid
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Test material form:
- solid
Constituent 1
impurity 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia Magna
Animals Daphnia Magna (Straus) used in the experiment were taken from own test laboratory culture. In the experiment animals in good physiological conditions, up to 24 hours old were used.
Daphnia Magna Culturing
The culture is maintained in 25 l aquariums at room temperature (20 to 22 oC) and natural photoperiod (daily light). The culture is maintained in standardized Elendt water M7. Pseudokirchneriella subcapitata algae suspension from own culture is used as a food for Daphnia. In addition to the algae suspension, Daphnia are fed with fresh yeast suspension or lyophilized Spirulina suspension as a source of vitamins of group B and microelements indispensable for proper growth of Daphnia population. Once a week Daphnia population is “depleted” to maintain bio-balance (too high concentration may lead to appearance of males and ephippia production, decline in physiological conditions and finally to population collapse). A day before the test set up, the mature animals were taken from culture to container of about 1 liter (with help of net with proper mesh size) Since Daphnia (cultured in proper way – i.e. without males and ephippia) reproduce partenogenetically young (less than 24 old) population of animals was obtained on the next day. These young Daphnia were used in tests.
Study design
- Test type:
- static
- Water media type:
- other: Elendt water M7
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20±1 oC
- pH:
- Information on pH is included in Table 1.
- Dissolved oxygen:
- Information on oxygene concentration is included in Table 1.
- Nominal and measured concentrations:
- Concentration
In the study test material was used in one concentration (limit test) – 100 mg/l. Concentration of test material was prepared by weighting of 10 mg of test material, precise mixing in 100 ml of Elendt water used in the test. And then, introducing to the system. Concentration of test material was determined by chemical analysis. - Details on test conditions:
- The test environment and the dilution medium used for preparing the test material solution was standardized Elendt water M7, the same like used in culture. The test was run in plastic test container of 100 ml capacity. Before test start Elendt water was aerated for 30 minutes. Test concentrations as well as control was set up in four replicates. The volume of test material solution in every replicate was 25 ml. Five individuals of Daphnia Magna were used per each replicate. (i.e. 20 animals per concentration). Therefore there was 5 ml of test solution per each animal (according to OECD Guideline there should be at least 2 ml). The test was run for 48 hours in natural photoperiod. The test was run in static manner Animals were not fed during the test and the temperature was maintained in range 20±1 oC. At the beginning of test and after 48 h pH values and content of dissolved oxygen were measured, the same measurements were performed for fresh solutions. Information on pH and oxygene concentration is included in Table 1.
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 100 mg/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 100 mg/L
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 after 48 h >100 mg/l
EC0 after 48 h ≥ 100 mg/l
EC100 after 48 h > 100 mg/l - Executive summary:
Observation and assessment
Observation and the results (mortality and immobility) were scored after 24 and 48 hours of exposure. The results were recorded on results sheets. The animals were regarded as dead or immobile of they show no ability to swim within 15 seconds after delicate shaking of the test container.
Toxicity of tested material to Daphnia magna is assessed as EC50 (median concentration causing immobilization i.e. inability to swim of 50% population after 24 and 48 hours of exposure, EC0 (the highest concentration causing no immobilization) and EC100(the lowest concentration causing 100% of immobilization). In case of no mortality was observed in test concentration the EC50/48 h is above this concentration, EC0 value is equal of above this concentration and EC100 is above this concentration.
Results and dusscusion
Validity criteria
All validity criteria were met:
- Mortality and immobilization of tested animals in control was 0% (criterion should not exceed 10%)
- Concentration of dissolved oxygen was higher than 3 mg/l
Final Results
Median concentration causing 50% immobilization of Daphnia magna population (EC50) after 48 hours was above 100 mg/l. EC0after 48 hous was above or equal 100 mg/l and EC100 after 48 hours was above 100 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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