Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-325-3 | CAS number: 24577-34-2
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- other: read-across target
Reference
- Endpoint:
- dermal absorption in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted on read-across material
- Justification for type of information:
- Read-across to structurally similar substance.
- Reason / purpose for cross-reference:
- read-across source
- Time point:
- 3 h
- Dose:
- 2000 mg/kg
- Parameter:
- percentage
- Absorption:
- 0 %
- Time point:
- 24 h
- Dose:
- 2000 mg/kg
- Parameter:
- percentage
- Absorption:
- 0 %
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 402
- Deviations:
- yes
- Remarks:
- Additional determination of dermal absorption of the test item (DOTL)
- Principles of method if other than guideline:
- Additional determination of dermal absorption of the test item (DOTL), via Sn in plasma
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dioctyltin dilaurate
- EC Number:
- 222-883-3
- EC Name:
- Dioctyltin dilaurate
- Cas Number:
- 3648-18-8
- Molecular formula:
- C40-H80-O4-Sn
- IUPAC Name:
- dioctyltin dilaurate
- Test material form:
- other: liquid; as such
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24h
- Doses:
- 2000 mg/kg bw
- No. of animals per group:
- 5 female, 5 male
- Control animals:
- no
Results and discussion
- Signs and symptoms of toxicity:
- no effects
- Dermal irritation:
- no effects
Percutaneous absorptionopen allclose all
- Time point:
- 3 h
- Dose:
- 2000 mg/kg
- Parameter:
- percentage
- Absorption:
- 0 %
- Time point:
- 24 h
- Dose:
- 2000 mg/kg
- Parameter:
- percentage
- Absorption:
- 0 %
- Conversion factor human vs. animal skin:
- Not relevant, since no absorption was detected
Applicant's summary and conclusion
- Conclusions:
- The study proves, that no test material has been absorbed via the dermal route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
