Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-042-3 | CAS number: 603-47-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- lack of many precisions
Data source
Reference
- Reference Type:
- publication
- Title:
- Final report on the safety assessment of Basic Violet 1, Basic Violet 3, and Basic Violet 4
- Author:
- C. Diamante et al.
- Year:
- 2 009
- Bibliographic source:
- International Journal of Toxicology, 28(Suppl 3) 193s-204s
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no information on the method
- GLP compliance:
- not specified
- Test type:
- other: not specified
Test material
- Reference substance name:
- 4-[[4-(dimethylamino)phenyl][4-(methylimino)cyclohexa-2,5-dien-1-ylidene]methyl]-N,N-dimethylaniline monohydrochloride
- EC Number:
- 210-042-3
- EC Name:
- 4-[[4-(dimethylamino)phenyl][4-(methylimino)cyclohexa-2,5-dien-1-ylidene]methyl]-N,N-dimethylaniline monohydrochloride
- Cas Number:
- 603-47-4
- Molecular formula:
- C24H27N3.ClH
- IUPAC Name:
- 4-[[4-(dimethylamino)phenyl][4-(methylimino)cyclohexa-2,5-dien-1-ylidene]methyl]-N,N-dimethylaniline monohydrochloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- 17 young rats and 12 adult rats (the dose and the sex are not specified).
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 160 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: young rats
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: adult rats
- Mortality:
- No information
- Clinical signs:
- other: No information
- Gross pathology:
- No information
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- When Basic Violet 1 was administered to 17 young and 12 adult rats (dose and sex not specified), the author states that the oral median lethal dose was greater than 2160 mg/kg for young rats and greater than 2600 mg/kg for adult rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
