1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactose

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

GLP compliance:

not specified

Type of method:

capillary method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Purity test date: production grade TGS (PG), purified TGS (P) and TGS containing niacinamide TGS (N)

Key result

Decomposition:

yes

Decomp. temp.:

ca. 114.5 °C

Remarks on result:

other: heating of 1°C per minute

Decomp. temp.:

125.5 °C

Remarks on result:

other: heating of 5°C per minute

Conclusions:

Decomposition of the test substance was observed using a Capillary tube in a metal block at temperatures at 114.5°C at a heating rate of 1°C per minute. Melting of the test substance was not observed below the temperature at which decomposition started. Based on this, the test substance has no melting temperature.

Executive summary:

On heating, TGS starts to decompose before its melting point. The temperature at which three grades of TGS convert from a decomposing solid phase to a decomposing liquid phase has been measured. The melting points of production grade the test substance, when heated from 10°C below their melting points at an approximate average rate of heating of 1°C per minute and corrected using National Physical Laboratory Chemical Reference Materials for the calibration of melting point apparatus are: 114.5 °C; at an approximate average rate of heating of 5°C per minute and the appropriate correction: 125.5 °C.

Description of key information

The melting point of the test substance was determined similar to OECD Guidelines for the Testing of Chemicals no. 102: "Melting Point / Melting Range" (July 27, 1995).

The decomposition temperature was determined to be 114.5°C.