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EC number: 244-033-0 | CAS number: 20780-48-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See attached justification
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981, 1992
- Deviations:
- yes
- Remarks:
- Observation period 7 days instead of 14 days
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- No data
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume): 0.5 ml
- Concentration (if solution): 100 % - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- Test 1: 3
Test 2 and 3: 4 - Details on study design:
- TEST SITE
- Area of exposure: flank
- % coverage: no data
- Type of wrap if used: semi-occlusive patches (multi-patch)
OBSERVATION TIME POINTS
1 hour and 1, 2, 3 and 7 days
SCORING SYSTEM: Draize scale, following OECD Test Guideline 404 (Erythema and Eschar formation / Oedema formation). Maximum possible score: 4 - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.9
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 1
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 1
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 2
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 2
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritant / corrosive response data:
- Marked and slight desquamation from skin surface appeared as follows:
- Test 1: at day 2, 3 and 7 (1 animal marked)
- Test 2: at day 1, 2, 3 and 7 (2 animals marked, 1 animal slight)
- Test 3: at day 3 and 7 (1 animal marked, 3 animals slight) - Other effects:
- No data
- Interpretation of results:
- other: not classified
- Remarks:
- based on CLP criteria
- Conclusions:
- Under the conditions of this study, mean erythema and edema scores in the animals in each test were not above 2.3 for the timepoints concerned for classification. However, some effects did not disappear within the 7 days observation period. Therefore the substance is considered to be irritating to skin and should be classified as such based on the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
Single 4-hour-exposure of Linalool (100% concentration) under semi-occlusive conditions in three independent experiments caused slight irritation on rabbit skin. A mean erythema score (24-72h) of at least 2 for at least 24 hours was observed in rabbits one of the three tests. Mean erythema values (24-72h) for each of the animals showed a maximum of 2 in all three tests. Erythema was still visible after 7 days. In addition desquamation was noted. Mean oedema scores were (24-72h) <1.4. Mean oedema values (24 -72h) for each of the animals showed a maximum of 1.7 in all three tests. Marked and slight desquamation from skin surface appeared at day 1, 2, 3, and 7 days. The skin responses (erythema and/or oedema) did not disappear in all animals after 7 days. Based on these data linalool is considered to be irritating to the rabbit skin. The substance needs to be classified as skin irritant according to the criteria outlined in Annex I of Regulation (EC)1272/2008.
Mean values (24 -72h) per animal per endpoint per test (used for CLP classification):
Irritation parameter | Basis | Time point | Score | Reversibility | Remarks |
Erythema score | Animal #1 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 1 |
Oedema score | Animal #1 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 1 |
Erythema score | Animal #2 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 1 |
Oedema score | Animal #2 | 24-72 hrs | 1.3 | Not fully reversible within: 7 days | Test 1 |
Erythema score | Animal #3 | 24-72 hrs | 1.7 | Fully revesible within: 7 days | Test 1 |
Oedema score | Animal #3 | 24-72 hrs | 1 | Not fully reversible within: 7 days | Test 1 |
Erythema score | Animal #1 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 2 |
Oedema score | Animal #1 | 24-72 hrs | 1.7 | Not fully reversible within: 7 days | Test 2 |
Erythema score | Animal #2 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 2 |
Oedema score | Animal #2 | 24-72 hrs | 1.7 | Fully revesible within: 7 days | Test 2 |
Erythema score | Animal #3 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 2 |
Oedema score | Animal #3 | 24-72 hrs | 1 | Not fully reversible within: 7 days | Test 2 |
Erythema score | Animal #4 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 2 |
Oedema score | Animal #4 | 24-72 hrs | 1 | Not fully reversible within: 7 days | Test 2 |
Erythema score | Animal #1 | 24-72 hrs | 1 | Fully revesible within: 7 days | Test 3 |
Oedema score | Animal #1 | 24-72 hrs | 0 | - | Test 3 |
Erythema score | Animal #2 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 3 |
Oedema score | Animal #2 | 24-72 hrs | 1 | Fully revesible within: 7 days | Test 3 |
Erythema score | Animal #3 | 24-72 hrs | 2 | Fully revesible within: 7 days | Test 3 |
Oedema score | Animal #3 | 24-72 hrs | 0.7 | Fully revesible within: 7 days | Test 3 |
Erythema score | Animal #4 | 24-72 hrs | 1.7 | Fully revesible within: 7 days | Test 3 |
Oedema score | Animal #4 | 24-72 hrs | 0 | - | Test 3 |
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test material
- Reference substance name:
- 3,7-dimethyloctan-3-yl acetate
- EC Number:
- 244-033-0
- EC Name:
- 3,7-dimethyloctan-3-yl acetate
- Cas Number:
- 20780-48-7
- Molecular formula:
- C12H24O2
- IUPAC Name:
- 3,7-dimethyloctan-3-yl acetate
- Test material form:
- liquid
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.9
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 1
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 1
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 2
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Test 3
- Irritant / corrosive response data:
- Marked and slight desquamation from skin surface appeared as follows:
- Test 1: at day 2, 3 and 7 (1 animal marked)
- Test 2: at day 1, 2, 3 and 7 (2 animals marked, 1 animal slight)
- Test 3: at day 3 and 7 (1 animal marked, 3 animals slight) - Other effects:
- No data
Any other information on results incl. tables
Mean values (24 -72h) per animal per endpoint per test (used for CLP classification):
Irritation parameter | Basis | Time point | Score | Reversibility | Remarks |
Erythema score | Animal #1 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 1 |
Oedema score | Animal #1 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 1 |
Erythema score | Animal #2 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 1 |
Oedema score | Animal #2 | 24-72 hrs | 1.3 | Not fully reversible within: 7 days | Test 1 |
Erythema score | Animal #3 | 24-72 hrs | 1.7 | Fully revesible within: 7 days | Test 1 |
Oedema score | Animal #3 | 24-72 hrs | 1 | Not fully reversible within: 7 days | Test 1 |
Erythema score | Animal #1 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 2 |
Oedema score | Animal #1 | 24-72 hrs | 1.7 | Not fully reversible within: 7 days | Test 2 |
Erythema score | Animal #2 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 2 |
Oedema score | Animal #2 | 24-72 hrs | 1.7 | Fully revesible within: 7 days | Test 2 |
Erythema score | Animal #3 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 2 |
Oedema score | Animal #3 | 24-72 hrs | 1 | Not fully reversible within: 7 days | Test 2 |
Erythema score | Animal #4 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 2 |
Oedema score | Animal #4 | 24-72 hrs | 1 | Not fully reversible within: 7 days | Test 2 |
Erythema score | Animal #1 | 24-72 hrs | 1 | Fully revesible within: 7 days | Test 3 |
Oedema score | Animal #1 | 24-72 hrs | 0 | - | Test 3 |
Erythema score | Animal #2 | 24-72 hrs | 2 | Not fully reversible within: 7 days | Test 3 |
Oedema score | Animal #2 | 24-72 hrs | 1 | Fully revesible within: 7 days | Test 3 |
Erythema score | Animal #3 | 24-72 hrs | 2 | Fully revesible within: 7 days | Test 3 |
Oedema score | Animal #3 | 24-72 hrs | 0.7 | Fully revesible within: 7 days | Test 3 |
Erythema score | Animal #4 | 24-72 hrs | 1.7 | Fully revesible within: 7 days | Test 3 |
Oedema score | Animal #4 | 24-72 hrs | 0 | - | Test 3 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- based on CLP criteria
- Conclusions:
- Under the conditions of this study, mean erythema and edema scores in the animals in each test were not above 2.3 for the timepoints concerned for classification. However, some effects did not disappear within the 7 days observation period. Therefore the substance is considered to be irritating to skin and should be classified as such based on the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC). This result was used for read-across to tetrahydrolinalyl acetate.
- Executive summary:
Single 4-hour-exposure of Linalool (100% concentration) under semi-occlusive conditions in three independent experiments caused slight irritation on rabbit skin. A mean erythema score (24-72h) of at least 2 for at least 24 hours was observed in rabbits one of the three tests. Mean erythema values (24-72h) for each of the animals showed a maximum of 2 in all three tests. Erythema was still visible after 7 days. In addition desquamation was noted. Mean oedema scores were (24-72h) <1.4. Mean oedema values (24 -72h) for each of the animals showed a maximum of 1.7 in all three tests. Marked and slight desquamation from skin surface appeared at day 1, 2, 3, and 7 days. The skin responses (erythema and/or oedema) did not disappear in all animals after 7 days. Based on these data linalool is considered to be irritating to the rabbit skin. The substance needs to be classified as skin irritant according to the criteria outlined in Annex I of Regulation (EC)1272/2008. This result was used for read-across to tetrahydrolinalyl acetate.
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