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Diss Factsheets
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EC number: 947-890-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Details on study design: HPLC method:
- Performance of the Test
Preparation of dead time solution
The dead time was determined by measuring the retention time of formamide (purity* 99.6%) at 646 mg/L solution in methanol.
Preparation of reference standard solutions
Solutions of reference standards (see following table) were prepared in methanol.
Standard Purity (%)* Concentration (mg/L)
Acetanilide 99+ 103
Atrazine 99.1 103
Triadimenol 98.0 100
Linuron 99.7 101
Naphthalene 99.0 110
Endosulfan-diol 99.9 104
Fenthion 97.5 112
Endosulfan 99.6 107
Phenanthrene ≥99.5 107
Diclofop-methyl 99.1 115
DDT 98.7 104
Preparation of sample solution
Test item (0.1997g) was diluted to 20 mL with tetrahydrofuran and further diluted by a factor of 10 to give a concentration of 0.999 g/L.
Determination of retention time
The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC System : Agilent Technologies 1200, incorporating workstation and autosampler
Detectors : Agilent variable wavelength detector (VWD)
evaporative light scattering (ELS)
Column : Waters XSelect HSS CN 5µm (150 x 4.6 mm id)
Column temperature : 30 °C
Mobile phase : methanol:water (55:45 v/v)
pH of mobile phase : 3.0, adjusted with trifluoroacetic acid
Flow-rate : 1.0 mL/min
Injection volume : 5 µL
VWD wavelength : 210 nm (dead time and reference standards)
ELSD parameters : nebuliser temperature: 40 °C
evaporator temperature: 80 °C
gas flow: 1.0 L/min
The mobile phase was ramped to 100% tetrahydrofuran shortly after the elution of the last reference standard in order to elute any highly retained test item components. This was carried out for the sample and sample blank injections only. - Key result
- Type:
- log Koc
- Value:
- >= 5.04 dimensionless
- pH:
- 3
- Remarks on result:
- other: the adsorption coefficient of the test substance was determined to be in the range 1.10 x 10E5 to >4.27 x 10E5, log10 Koc of 5.04 to > 5.63
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the adsorption coefficient of the test substance has been determined to be in the range of 1.10+E5 to >4.27+E5, log10 Koc of 5.04 to >5.63. This result classifies the test substance as immobile.
- Executive summary:
A study was conducted to determine adsorption/desorption coefficient of the test substance. The determination was carried out using the HPLC screening method, designed to be compatible with OECD Guideline 121 and EU Method C.19. The test system utilized a high performance liquid chromatograph (HPLC). A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. Under the study conditions, the adsorption coefficient of the test substance wasdetermined to be in the range of 1.10+E5 to >4.27+E5, log10 Koc of 5.04 to > 5.63. This result classifies the test substance as immobile (Envigo, 2018).
Reference
Results
The retention times of the dead time and the retention times, capacity factors (k') and log10 Koc values for the reference standards are shown in the following table:
Table 8
Standard |
Retention Time (min) |
Mean Retention Time (min) |
Capacity Factor (k') |
Log10k' |
Log10Koc |
|
Injection 1 |
Injection 2 |
|||||
Formamide (dead time) |
1.914 |
1.910 |
1.912 |
- |
- |
- |
Acetanilide |
2.629 |
2.629 |
2.629 |
0.375 |
-0.426 |
1.25 |
Atrazine |
3.620 |
3.615 |
3.618 |
0.892 |
-4.96 x 10-2 |
1.81 |
Triadimenol |
5.214 |
5.214 |
5.214 |
1.727 |
0.237 |
2.40 |
Linuron |
5.369 |
5.369 |
5.369 |
1.808 |
0.257 |
2.59 |
Naphthalene |
4.636 |
4.636 |
4.636 |
1.424 |
0.154 |
2.75 |
Endosulfan-diol |
6.710 |
6.710 |
6.710 |
2.510 |
0.400 |
3.02 |
Fenthion |
7.935 |
7.940 |
7.937 |
3.151 |
0.498 |
3.31 |
a-Endosulfan |
11.341 |
11.346 |
11.344 |
4.933 |
0.693 |
4.09 |
Diclofop-methyl |
12.187 |
12.191 |
12.189 |
5.375 |
0.730 |
4.20 |
Phenanthrene |
8.683 |
8.683 |
8.683 |
3.541 |
0.549 |
4.09 |
DDT |
24.057 |
24.062 |
24.06 |
11.583 |
1.06 |
5.63 |
The calibration curve from which the sample results were taken from is shown as Figure 3 - attached to this Summary.
Adsorption Coefficient
The retention times, capacity factor and log10Kocvalue determined for the sample are shown in the following table:
Table 9
Peak |
Injection |
Retention Time (min) |
Capacity Factor (k') |
Log10k' |
Log10Koc |
Mean |
|||||||
1 |
1 |
19.252 |
9.07 |
0.958 |
5.04 |
5.04 |
|||||||
2 |
19.341 |
9.12 |
0.960 |
5.04 |
|||||||||
2 |
1 |
24.477 |
>11.6 |
>1.06 |
>5.63 |
>5.63 |
|||||||
2 |
24.539 |
>11.6 |
>1.06 |
>5.63 |
|||||||||
3 to 6 |
1 |
≥34.100 |
>11.6 |
>1.06 |
>5.63 |
>5.63 |
|||||||
2 |
≥34.106 |
>11.6 |
>1.06 |
>5.63 |
Overall log10Koc:
5.04 to > 5.63
Overall adsorption coefficient: 1.10 x 105 to >4.27 x 105
Description of key information
Key value for chemical safety assessment
- Koc at 20 °C:
- 5.04
Additional information
A study was conducted to determine adsorption/desorption coefficient of the test substance. The determination was carried out using the HPLC screening method, designed to be compatible with OECD Guideline 121 and EU Method C.19. The test system utilized a high performance liquid chromatograph (HPLC). A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. Under the study conditions, the adsorption coefficient of the test substance was determined to be in the range of 1.10+E5 to >4.27+E5, log10 Koc of 5.04 to > 5.63. This result classifies the test substance as immobile (Envigo, 2018).
[LogKoc: 0.702]
[LogKoc: 0.702]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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