Registration Dossier
Registration Dossier
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EC number: 257-843-4 | CAS number: 52315-75-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route and no systemic effects have been observed in in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation)
- Justification for type of information:
- In an acute oral toxicity study with ICR mice the dosing with up to 3000 mg/kg bw caused no adverse effects, i.e. the oral LD50 value of the test item is > 3000 mg/kg bw. A Draize test comparable to OECD Guideline 404 gave no indication for adverse systemic effects and there was also no indication for a skin irritating potential of the test item. Also in a GPMT comparable to OECD Guideline 406 the test item caused no adverse effects and gave no indication for a skin sensitisation potential.
Therefore, due to animal welfare reasons, further experimental testing with dermal exposure at present is scientifically not justified.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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