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EC number: 219-834-3 | CAS number: 2549-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Vinyl chloroacetate
- EC Number:
- 219-834-3
- EC Name:
- Vinyl chloroacetate
- Cas Number:
- 2549-51-1
- Molecular formula:
- C4H5ClO2
- IUPAC Name:
- ethenyl 2-chloroacetate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature in the dark
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: David Percival Lts, Moston, Sandbach, Cheshire, UK
- Age at study initiation: 12 - 16 weeks old
- Weight at study initiation: 2.69 - 2.82 kg
- Housing: suspended metal cages
- Diet (e.g. ad libitum): free access to STANRAB SQC Rabbit Diet allowed throughout the day
- Water (e.g. ad libitum): free access to mains tap water allowed throughout the day
- Acclimation period: minimum 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 hrs / 12 hrs dark
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm cotton gauze patch
- Type of wrap if used: each patch was secured in position with a strip of surgical adhesive tape (BLENDERM: approx size 2.5 x 4.0 cm), and to prevent the rabbit interfering with the patches, the trunk of the rabbit was wrapped in elasticated corset (TUBIGRIP).
REMOVAL OF TEST SUBSTANCE
- Washing (if done): any residual test material was removed by gentle swabbing with cotton wool soaked in 74% Industrial Methylated Spirits
OBSERVATION TIME POINTS
1 hour, 24 hours, 48 hours and 72 hours. Additional observations were made on Days 7 and 14 to assess the reversibility of skin reactions.
SCORING SYSTEM:
Draize classification scheme
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2.33
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.67
- Irritant / corrosive response data:
- Well defined erythema was noted at all treated skin sites one hour after patch removal and at subsequent 24, 48 and 72 hour observations.
Slight oedema was noted at all treated skin sites one hour after patch removal. Moderate oedema was noted at one treated skin site with slight oedema at two treated skin sites at the 24 hr observation. Slight oedema was noted at all treated skin sites at the 48 hr observation. Slight oedema was noted at all treated skin sites with very slight oedema at the remaining treated skin site at the 72 hr observation. Slight oedema persisted at one treated skin site with very slight oedema at one other treated skin site at the 7 day observation.
Light brown discolouration of the epidermis was noted at two treated skin sites at the 24, 48 and 72 hr observations with loss of skin elasticity noted at the remaining treated skin site at the 48 and 72 hr observations. Crust formation was noted at all treated skin sites at the 7 day observation and precluded the evaluation of erythema at two treated skin sites at this time. Reduced regrowth of fur was noted at one treated skin site at the 14 day observation.
Two treated skin sites appeared normal at the 14 day observation. - Other effects:
- - Other adverse local effects: light brown discolouration of the epidermis, loss of skin elasticity, crust formation, reduced regrowth of fur observed at some treated sites
Any other information on results incl. tables
see 'attached background material'
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test material produced positive criteria in 3/3 rabbits. It produced a primary irritation index of 4.0 and was classified as a moderate irritant to rabbit skin according to the Draize classification scheme. The test substance meets the criteria for classification as Skin Irrit. 2; H315 according to Regulation (EC) No.1272/2008.
- Executive summary:
A GLP study was performed according to the OECD Guideline 404, to assess the irritancy potential of Vinyl Chloroacetate to the skin of the New Zealand White rabbit. A single 4 hr semi-occluded application of the test material to the intact skin of 3 rabbits produced well defined erythema and slight to moderate oedema. Light brown discolouration of the epidermis, loss of skin elasticity, reduced regrowth of fur and crust formation were also noted. Two treated skin sites appeared normal at the 14 day observation. 3 min and 1 hr semi-occluded applications of the test material produced no corrosive effects.
The test material produced positive criteria in 3/3 rabbits. It produced a primary irritation index of 4.0 and was classified as a moderate irritant to rabbit skin according to the Draize classification scheme. The test substance meets the criteria for classification as Skin Irrit. 2; H315 according to Regulation (EC) No.1272/2008.
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