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Diss Factsheets
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EC number: 947-716-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
BCF = 222 L/kg (fu =1) in RT- S9 system (Rainbow Trout liver S9 subceluular fraction, fu=1assumes all the material is available for biotransformation)
BCF = 216 L/kg (fu =1) in RT- HEP system (Rainbow Trout Hepatocytes, fu=1assumes all the material is available for biotransformation)
Key value for chemical safety assessment
- BCF (aquatic species):
- 222 L/kg ww
Additional information
The BCF of test item was performed using the in vitro metabolism technology with trout liver S9 sub-cellular fractions (RT-S9) and cryopreserved hepatocytes (RT-HEP)in accordance with OECD guideline 319B/A. The test item was incubated with a particular set of incubation conditions that included time, concentration (μM) and protein concentration (S9 fraction) or cell density (cryopreserved hepatocytes) previously determined during preliminary or range finding incubations.The depletion of the parent compound was analyzed using a GC-MS. The metabolic rate was calculated as described in the testing guideline. Thereafter, the resulted metabolic rate and experimental data of the partition coefficient log Pow were given as input parameters into the in vitro to in vivo extrapolation (IVIVE) model. The BCF-values were calculated to be 222 L/kg (fu=1) and 1051.0 L/kg (fu, modeled) in the RT-S9 system and 216 L/kg (fu=1) and 988 L/kg (fu, modeled) in the RT-HEP system, respectively.
Since BCF values obtained from in vitro studies based on fu=1 appear to be the closest to those observed in in vivo tests (Lapczynski at al., 2018; Laue et at al.,2015). The highest value of 222 L/kg was used for the risk assessment and PBT-assessment. According to section 1 of Annex XIII of the REACH regulation (EC) No 1907/2006the test item was considered as neither bioaccumulative (B) nor very bioaccumulative (vB).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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