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EC number: 211-284-2 | CAS number: 637-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2017-03-22 to 2017-04-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- 180.24 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Decomp. temp.:
- 245.79 °C
- Sublimation:
- no
- Conclusions:
- The melting point (first event) was determined to be 180.24 ± 0.23 °C (453.39 ± 0.23 K). These values are the means of three independent determinations.
The decomposition point (second event) was determine to be 245.79 °C (518.94 K), which is the mean of two determinations. - Executive summary:
A study was conducted according to OECD TG 102 and Regulation (EC) No. 440/2008, method A.1 in order to determine the melting point of the test item by using DSC method (differential scanning calorimetry). In the pre-test for melting range the test item melted to a clear slightly brownish solution (range of 181.8 and 186.1 °C. After cooling down, the test item was solidified to a slightly brown mass.
Referring to the pre-test, the melting point was determined as the first event (endothermic) with: 180.24 ± 0.23 °C (453.39 ± 0.23 K). These values are the means of three independent determinations. The second event evaluated with the event marker function of the DSC software was indicated as beginning of decomposition with: 245.79 °C (518.94 K). No observations were made which might cause doubts on the validity of the study outcome (difference between determinations was below 0.5 K). Therefore, the result of the study is considered valid.
Reference
Pre-test for melting range
The capillary tube containing the test item was set into the block at 20.2 °C. The block was heated until melting started. The temperature was noted at which the first signs of melting of the test item were observed. When the substance was completely melted, the temperature was noted again.
Melting point/range: begin 181.8 °C; end 186.1 °C
Observations: The test item melted to a clear slightly brownish solution. After cooling down, the test item was solidified to a slightly brown mass.
Security pre-test for DSC instrument
The crucible was found visually unchanged after reaching a temperature of 220 °C. The weight was recorded at 49.13 mg. After heating the crucible was opened, the test item was red-brown solid and bonded together. The test item decomposed.
Calibration
For calibration indium and zinc were used. The measurement of indium after calibration met the validity criteria.
DSC measurement of test item
In order to have more information for the evaluation three more determinations with temperatures from 15 – 250 °C (second determination), from 15 – 300 °C (third determination) and from 15 – 400 °C (fourth determination), respectively, were performed. Note: As the deviation between the first and the second determination was > 0.5 °C a third determination was performed. The fourth determination was performed in order to confirm results of the second and the third determination.
Final results
Observations
Table 1: Values and observations from all DSC measurements
Mass test item |
Mass crucible (before measurement): |
Mass crucible (after measurement): |
Observations | |
First Measurement |
1.39 mg | 46.91 mg | 46.93 mg | After the test the crucible was visually unchanged. The crucible was opened, the white solid mass test item was observed. |
Second Measurement |
1.45 mg | 47.13 mg | 47.09 mg | After the test the crucible was visually unchanged. The crucible was opened, the orange solid mass test item was observed. |
Third Measurement |
1.38 mg | 47.61 mg | 46.99 mg | After the test the crucible was visually unchanged. The crucible was opened, the brown-black test item was observed. |
Fourth Measurement |
1.79 mg | 47.72 mg | 46.21 mg | After the test the crucible was visually unchanged. |
Interpretation of the measurements
Based on the observations of the pre-test the first event (endotherm) was indicated as melting point and the second event was indicated as decomposition of the test item evaluated with event marker function.
Presentation of results
For the calculation of the values of the mean and the standard deviation, the first determination was not taken into account for the melting point.
Table 2: Determination of melting point
Melting point | in °C | in K |
1. Determination | 181.91 | 455.06 |
2. Determination | 180.48 | 453.63 |
3. Determination | 180.22 | 453.37 |
4. Determination | 180.02 | 453.17 |
First determination was not used for evaluation. | ||
Mean | 180.24 | 453.39 |
Standard deviation | 0.23 | 0.23 |
Table 3: Determination of decomposition
Decomposition | in °C | in K |
3. Determination | 247.45 | 520.60 |
4. Determination | 245.79 | 518.94 |
Decomposition begins | 245.79 | 518.94 |
As the difference between the three evaluated determinations was below 0.5 K the result of the melting point can be considered valid.
Description of key information
The melting point (first event) was determined to be 180.24 ± 0.23 °C (453.39 ± 0.23 K). These values are the means of three independent determinations.
The decomposition point (second event) was determine to be 245.79 °C (518.94 K), which is the mean of two determinations.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 180.24 °C
Additional information
A study was conducted according to OECD TG 102 and Regulation (EC) No. 440/2008, method A.1 in order to determine the melting point of the test item by using DSC method (differential scanning calorimetry). In the pre-test for melting range the test item melted to a clear slightly brownish solution (range of 181.8 and 186.1 °C. After cooling down, the test item was solidified to a slightly brown mass. Referring to the pre-test, the melting point was determined as the first event (endothermic) with: 180.24 ± 0.23 °C (453.39 ± 0.23 K). These values are the means of three independent determinations. The second event evaluated with the event marker function of the DSC software was indicated as beginning of decomposition with: 245.79 °C (518.94 K). No observations were made which might cause doubts on the validity of the study outcome (difference between determinations was below 0.5 K). Therefore, the result of the study is considered valid (reference 4.2 -1).
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