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EC number: 246-045-1 | CAS number: 24157-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation, in vivo (similar OECD 406): not sensitising
Read-across from analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9)
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 15% TS in vehicle
- No. with + reactions:
- 17
- Total no. in group:
- 20
- Clinical observations:
- no findings reported grading score (mean): 0.58
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Sterner, 1986
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 15% TS in vehicle
- No. with + reactions:
- 7
- Total no. in group:
- 20
- Clinical observations:
- no findings reported grading score (mean): 0.23
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Sterner, 1986
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 15% TS in vehicle
- No. with + reactions:
- 18
- Total no. in group:
- 20
- Clinical observations:
- no findings reported grading score (mean): 1.13
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Sterner, 1986
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 15% TS in vehicle
- No. with + reactions:
- 20
- Total no. in group:
- 20
- Clinical observations:
- no findings reported grading score (mean): 0.75
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Sterner, 1986
- Group:
- positive control
- Remarks on result:
- other: no information given in study report
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- In a guinea pig maximisation test (GPMT), no skin sensitisation was observed following occlusive epicutaneous challenge after induction treatments (intradermal injection and occlusive epicutaneous exposure).
- Executive summary:
The skin sensitisation potential of the target substance is predicted based on an adequate and reliable in vivo study of a structural analogue source substance. In a guinea pig maximisation test (GPMT) , no skin sensitisation was observed following occlusive epicutaneous challenge after induction treatments (intracutaneous injection and occlusive epicutaneous exposure). As explained in the analogue justification, the differences in molecular structure between the target and the source substances are unlikely to lead to differences in the skin sensitisation potential.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data on skin sensitisation with 2,6-diisopropylnaphthalene (CAS 24157-81-1) are available. This endpoint, therefore, is assessed by means of read-across from the analogue source substance bis(isopropyl)naphthalene (CAS 38640-62-9).
In a valid guinea pig maximisation test similar to OECD guideline 406 under GLP conditions, Pirbright white guinea pigs (20/group) were induced with a single intradermal injection of bis(isopropyl)naphthalene (CAS No. 38640-62-9) at 10% (in water, containing the emulsifier Cremophor) using the adjuvant complete Freund and an epicutaneous application of the test substance at 10% (in water, containing the emulsifier Cremophor) on the injection site. Epicutaneous challenge exposure was conducted 20 days after the first induction for 24 h under occlusive conditions. 15% of the test substance was applied on the flank of the animals. Evaluation of skin reactions was carried out 24 and 48 h after challenge. No information on positive controls was given in the study report. The test group, as well as the negative control group, showed erythema after 24 and 48 h, with scores ranging predominantly from 0.5 (slight, irregular erythema) to 1 (slight, continuous erythema) and 2 (moderate erythema). There was no significant difference between the test and control groups. In conclusion, in this guinea pig maximisation test slight to moderate erythema were induced after challenge exposure in control as well as in test group animals. The test substance, therefore, did not induce skin sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitisation for the analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9) do not meet the criteria for classification according to Regulation (EC) No. 1272/2008 (CLP). Data are, therefore, conclusive but not sufficient for classification. Based on an analogue read-across approach, the target substance 2,6-diisopropylnaphthalene (CAS No. 24157-81-1) also does not warrant classification for skin sensitisation.
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