6,6'-di-tert-butyl-2,2'-thiodi-p-cresol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

29 January 2018 to 06 February 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Commission Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Method A.6. “Water Solubility”, Official Journal of the European Union L 142 of 31 May

Deviations:

yes

Remarks:

The temperature was out of the required temperature range in 2 occasions with a maximum of 0.5 °C difference. This difference is not significant, so it has no effect to the Study results.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 105, "Water Solubility", adopted July 27, 1995

Deviations:

yes

Remarks:

The temperature was out of the required temperature range in 2 occasions with a maximum of 0.5 °C difference. This difference is not significant, so it has no effect to the Study results.

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Specific details on test material used for the study:

No further details specified in the study report.

Key result

Water solubility:

< 8 µg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

> 7.06 - < 7.19

Details on results:

Calibration
Seven concentration levels were tested: 0.001, 0.002, 0.005, 0.02, 0.05, 0.2 and 0.5 µg/mL. The calibration graph was calculated applying weighted linear regression using 1/concentration as weighting factor.

Results of the Column Elution Method
pH of the samples varied in the range of 7.06-7.19.
Samples were analysed with the above HPLC method. The samples were detectable, but their areas were significantly lower than area of lowest calibration. Control water was measured as well in every case, but peak was not detected in control samples

Measured concentration of test item from micro-columns

Time (day)	Micro-column I (~25 mL/h)		Micro-column II (~12.5 mL/h)
	Measured concentration mg/L	pH	Measured concentration mg/L	pH
1	<LOQ	7.08	<LOQ	7.14
	<LOQ	7.11	<LOQ	7.17
2	<LOQ	7.09	<LOQ	7.08
	<LOQ	7.10	<LOQ	7.09
3	<LOQ	7.12	<LOQ	7.18
	<LOQ	7.14	<LOQ	7.19
4	<LOQ	7.21	<LOQ	7.16
	<LOQ	7.18	<LOQ	7.17
7	<LOQ	7.06	<LOQ	7.06
	<LOQ	7.08	<LOQ	7.07
8	<LOQ	7.11	<LOQ	7.19
	<LOQ	7.16	<LOQ	7.17
Mean	<LOQ	-	<LOQ	-

 

Conclusions:

In conclusion, the water solubility of 6,6’-di-tert-butyl-2,2’-thiodi-p-cresol was determined to be below the quantification limit after 8 days equilibration time, considering to the dilution rate, the water solubility of test item is less than 8 µg/L at 20°C ± 0.5°C using the column elution method.

Executive summary:

The water solubility of 6,6’-di-tert-butyl-2,2’-thiodi-p-cresol was determined using the column elution method. It was found to be less than 8 µg/L at 20°C ± 0.5°C after 8 days equilibration time.

Description of key information

The water solubility is less than 8 µg/L at 20°C ± 0.5°C.

Key value for chemical safety assessment

Water solubility:

8 µg/L

at the temperature of:

20 °C

Additional information

The water solubility of 6,6’-di-tert-butyl-2,2’-thiodi-p-cresol was determined using the column elution method. It was found to be less than 8 µg/L at 20°C ± 0.5°C after 8 days equilibration time.