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EC number: 221-493-0 | CAS number: 3119-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-B (Determination of the "Ready" Biodegradability - Modified OECD Screening Test)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-amino-2,4,6-triiodobenzoic acid
- EC Number:
- 221-493-0
- EC Name:
- 3-amino-2,4,6-triiodobenzoic acid
- Cas Number:
- 3119-15-1
- Molecular formula:
- C7H4I3NO2
- IUPAC Name:
- 3-amino-2,4,6-triiodobenzoic acid
- Test material form:
- solid: bulk
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Schering AG, batch no. 37055008
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Municipal sewage treatment plant
- Storage conditions: under aerobic conditions
- Preparation of inoculum for exposure: 1 g of sodium acetate (ref. substance) was dissolved in 1000 mL aqua dest. 1 g of test substance was dissolved in 1000 mL aqua dest. The stock solution of the test substance was analyzed for TOC and for DOC, resulting in 42 mg/L TOC and 43 mg/L DOC repectively.
- Concentration of sludge: The final concentration of hte test and reference sustances was approximately 20 mg DOC in a volume of 1000 mL. In order to reach the final concentration, the following quantities of the different solutions were mixed:
Test substance (ZK2218): 476.2 mL of stock solution, 15 mL nutrient solution, 0.5 mL inoculum, and 508.3 mL aqua dest.
Reference (sodium acetate): 65.9 mL of the stock solution, 15 mL nutrient solution, 0.5 mL inoculum, and 918.6 mL aqua dest. - Duration of test (contact time):
- 42 d
Initial test substance concentration
- Initial conc.:
- 20 other: mg/1000 mL
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Test temperature: 20-25 C
- pH: 7.5 - 7.9
- pH adjusted: no
- CEC (meq/100 g):
- Aeration of dilution water: yes
- Continuous darkness: yes
- Other:
TEST SYSTEM
- Culturing apparatus: 2-litre class beakers
- Number of culture flasks/concentration: 3
- Method used to create aerobic conditions: initial aeration
- Measuring equipment: carbon analyzer
- Test performed in open system: yes
SAMPLING
- Sampling frequency: 1, 2, 5, 8, 15, 22, 28, 29, 36, and 43 days
- Sampling method: carbon analysis was performed by injecting aliquotes of the solution into the carbon analyzer.
CONTROL AND BLANK SYSTEM
- Inoculum blank: 15 mL nutrient solution, 0.5 mL inoculum, and 984.5 mL aqua dest.
- Toxicity control: Toxicity control (ZK2218 + sodium acetate): 65.9 mL of the sodium acetate stock solution, 476.2 mL of the ZK2218 stock solution, 15 mL nutrient solution, 0.5 mL inoculum, and 442.4 mL aqua dest.
Reference substance
- Reference substance:
- other: sodium acetate
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (DOC removal)
- Remarks:
- mean of 3 flasks
- Value:
- 21.1
- St. dev.:
- 0.53
- Sampling time:
- 1 d
- Parameter:
- % degradation (DOC removal)
- Remarks:
- Mean of 3 flasks
- Value:
- 19.47
- St. dev.:
- 0.24
- Sampling time:
- 15 d
- Parameter:
- % degradation (DOC removal)
- Remarks:
- mean of 3 flasks
- Value:
- 23.56
- St. dev.:
- 0.97
- Sampling time:
- 43 d
- Parameter:
- % degradation (DOC removal)
- Remarks:
- mean of 3 flasks
- Value:
- 18.41
- St. dev.:
- 1.8
- Sampling time:
- 28 d
- Details on results:
- The test substance ZK2218 showed no relevant degradation. The final degradation was 0%. The reference compound sodium acetate was degraded to 87% on day 5 (after 4 days of incubation). In the toxicity control, the reference substance, sodium acetate, plus the test substance was degraded up to 60% on day 36 (after 35 days of incubation). The degradation in the toxicity control reflected the degradation observed in the individual sets.
BOD5 / COD results
BOD5 / COD
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test substance was not readily biodegradable under the test conditions, according to OECD 301E and EU Method C.4B.
- Executive summary:
The test substance was not readily biodegradable under the test conditions, according to OECD 301E and EU Method C.4B, which resulted in 21.1%, 19.47%, 18.41%, and 23.56% degradation (DOC removal) at 1, 15, 28, and 43 days, repectively.
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