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EC number: 239-914-1 | CAS number: 15816-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- An 48-hour EC50 immobilization value of 8 mg/L was found for the crustacea Daphnia magna (water flea).
- Executive summary:
An 48-hour EC50 immobilization value of 8 mg/L was found for the crustacea Daphnia magna (water flea).
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Nov -17 Nov 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: stock solution (10 g/100 mL) was prepared while using ultrasound, aliquots were pipetted into test vessel and filled up with standard dilution water
- Controls: 1 - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water-flea
- Source: in-house culture
- Feeding during test: none
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 14 °dH (80 mg Ca and 12.2 mg Mg/L)
- Test temperature:
- 20.5 - 21.0 °C (room temperature)
- pH:
- 4.7 - 8.1, this is out of the recommended range of 6 - 9
- Dissolved oxygen:
- 76 - 85 %
- Nominal and measured concentrations:
- nominal: 10, 30, 100, 300, 1000, 3000, 10000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Material, size, headspace, fill volume of test vessel: glass beakers, covered with glass plates
- No. of organisms per vessel: 20
- No. of vessels per concentration: 1
- No. of vessels per control: 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deion. water with 294 mg CaCl2 * 2 H2O, 123 mg MgSO4 * 7 H2O, 63 mg NaHCO3, 5.5 mg KCl
OTHER TEST CONDITIONS
- Photoperiod: 16 h
EFFECT PARAMETERS MEASURED: immobility after 48 h - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 300 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 550 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: at concentrations of 1000, 3000 and 10000 mg/L all daphnids were unable to swim. At 100 mg/L, 5 % were unable to swim
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute toxicity of Octanoic acid to Daphnia magna was determined using a screening method similar to OECD Guideline 202. The number of daphnids per concentration were 20 and the substance concentration was not followed by chemical analysis. The product was tested in a concentration range of 10 to 10000 mg active matter /l (nominal). The incubation period was 48 hours under static conditions (the test-solutions were not renewed). Following results were obtained:
EC0 : 300 mg active matter /l
EC50 : 550 mg active matter! l
EC100 : 1000 mg active matter / l - Executive summary:
The acute toxicity of Octanoic acid to Daphnia magna was determined using a screening method similar to OECD Guideline 202. The number of daphnids per concentration were 20 and the substance concentration was not followed by chemical analysis. The product was tested in a concentration range of 10 to 10000 mg active matter /l (nominal). The incubation period was 48 hours under static conditions (the test-solutions were not renewed). Following results were obtained:
EC0 : 300 mg active matter /l
EC50 : 550 mg active matter! l
EC100 : 1000 mg active matter / l
Referenceopen allclose all
Table 1: Immobilisation of daphnids [%] after 48 h
Nominal test concentration [mg a.s./L] |
Immobilisation [%] |
0 (control) |
0 |
10 |
0 |
30 |
0 |
100 |
5 |
300 |
0 |
1000 |
100 |
3000 |
100 |
10000 |
100 |
Description of key information
DCHA:
An 48-hour EC50 immobilization value of 8 mg/L was found for the crustacea Daphnia magna (water flea).
Octanoic acid:
The acute toxicity of Octanoic acid to Daphnia magna was determined using a screening method similar to OECD Guideline 202.
Following results were obtained:
EC0 : 300 mg active matter /l
EC50 : 550 mg active matter! l
EC100 : 1000 mg active matter / l
Since the substance to be registered is Octanoic acid, compound with dicyclohexylamine (1:1) which will dissociate to 1 mol octanoic acid and 1 mol dicyclohexylamine, the lowest EC50 of 8 mg/l for dicyclohexylamine is used for calculating the EC50 for the entire substance considering the molar mass of 325.5 g/mol (55.7% dicyclohexylamine).
Therefore the EC50 for freshwater invertebrates for Octanoic acid, compound with dicyclohexylamine (1:1) is 14.4 mg/ml.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 14.4 mg/L
Additional information
Read Across justification:
In aqueous systems Octanoic acid, compound with dicyclohexylamine (1:1) is hydrolytically very unstable so that in aqueous solution a rapid decomposition to the educts can be observed. The substance will rapidly dissociate to octanoic acid and dicyclohexylamine. Therefore Octanoic acid, compound with dicyclohexylamine (1:1) is not stable at “standard” testing conditions representative for human and environmental exposure. Hence, it is fully justified to apply the read-across methodology by use of the respective data from the breakdown/decomposition products to describe the (eco)toxicological behaviour of the substance to be registered.
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