Registration Dossier

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
CRC Handbook of chemistry and physics.
Author:
Lide, D.R.
Year:
1993
Bibliographic source:
73th edition, 1992-1993, ISBN 0-8493-0473-3

Materials and methods

Principles of method if other than guideline:
No information is available on the testing protocol.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Dissosciation constantopen allclose all
No.:
#1
pKa:
2.2
Temp.:
21 °C
Remarks on result:
other: pKa: Negative of the logarithm of the dissociation constant for the alpha-COOH group
No.:
#2
pKa:
9.11
Temp.:
21 °C
Remarks on result:
other: pKb: Negative of the logarithm of the dissociation constant for the alpha-NH3+ group
No.:
#3
pKa:
10.07
Temp.:
21 °C
Remarks on result:
other: pKx: Negative of the logarithm of the dissociation constant for any group present in the molecule.

Applicant's summary and conclusion

Conclusions:
The pKa is 2.2 and the pKb is 9.11.