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EC number: 208-904-9 | CAS number: 546-56-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
No sediment toxicity data are currently available for the registered substance.
Long-term sediment toxicity studies are not required for Annex VIII substances under the REACH Regulation. However, due to the high sediment adsorption potential of the substance and the potential for persistence in the sediment, it is appropriate to assess the potential significance of this compartment as part of the chemical safety assessment. Data have been read across from a structural analogue within the Siloxanes Category for the purpose of deriving PNEC and conducting a quantitative environmental risk characterisation.
A 28-d EC50 value of >130 mg/kg sediment dry weight and a NOEC of 130 mg/kg sediment dry weight have been determined for effects on growth rate of Hyalella azteca. The results are read-across from decamethylcyclopentasiloxne (D5) CAS 541-02-6.
Key value for chemical safety assessment
- EC10, LC10 or NOEC for freshwater sediment:
- 130 mg/kg sediment dw
Additional information
Long-term sediment toxicity studies are not required for Annex VIII substances under the REACH Regulation. However, due to the high sediment adsorption potential of the substance and the potential for persistence in the sediment, the compartment has been assessed.
A result for effects in natural sediment on the invertebrate amphipod Hyalella azteca is read across from decamethylcyclopentasiloxane (D5), CAS 541-02-6. The result from that test is a 28 d EC50 value of >130 mg/kg sediment dry weight for growth rate and a NOEC of 130 mg/kg sediment dry weight for growth rate.
The following results have been obtained in two tests performed with another read-across substance (D6) using natural sediment:
A 28-d EC50 value of >420 mg/kg dry weight and a NOEC of ≥420 mg/kg dry weight have been determined for effects on numbers and biomass of Lumbriculus variegatus. A 28-d EC50 value of >620 mg/kg dry weight and a NOEC of ≥620 mg/kg dry weight have been determined for effects on emergence and development rate of Chironomus riparius.
A test with Chiromomus riparius exposed via artificial sediment gave a 28 -Day EC50 value of 37 mg/kg dry weight for the effects of the registered substance (D6) on mortality and a NOEC of <22 mg/kg dry weight for effects on development rate and development time. However, the result is disregarded because a result for the same species is available from a test with natural sediment.
The results of all tests are expressed relative to mean measured exposure concentrations in the treated sediment.
A NOEC value of 130 mg/kg dw sediment for effects on Hyalella azteca is used as the key value for the CSA.
A total of twenty-one sediment toxicity studies for siloxanes are available and sixteen results from studies of standard duration in standard test species have been reviewed in detail. There is a general trend for studies using natural sediment, which all have pH <~8, to show no effects, or higher NOECs than those with artificial sediment. No significant toxicity (NOEC <100 mg/kg) in any organism is found at pH near 7 with natural sediment. The data suggest that it is possible to read across sediment toxicity data between different siloxane structures, especially where natural sediment data are available, given that the sound studies show relatively minimal effects across the dataset. In the use of the data set for hazard assessment and derivation of predicted no-effect concentration (PNEC), the following approaches are used:
- Where the hydrolysis half-life is >48 hours, the chemical safety assessment will focus on the parent form.
- Where data are available for a substance with natural sediment and with artificial sediment for the same species, the natural sediment data will be given preference over data obtained with artificial sediment.
- PNEC will be determined on a weight-of-evidence basis for each substance, including use of read-across. Equilibrium partitioning calculations will be used if necessary.
REFERENCE:
Peter Fisk Associates (2017i), Peter Fisk Associates. Siloxane Category report for environmental endpoints. PFA.404.114.001
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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