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EC number: 271-517-9 | CAS number: 68583-52-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 19, 1995 to October 13, 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- Version / remarks:
- July 1, 1991
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Decanoic acid, mixed diesters with octanoic acid and triethylene glycol
- EC Number:
- 271-517-9
- EC Name:
- Decanoic acid, mixed diesters with octanoic acid and triethylene glycol
- Cas Number:
- 68583-52-8
- Molecular formula:
- C10-H20-O2.C8-H16-O2.C6-H14-O4
- IUPAC Name:
- Decanoic acid, mixed diesters with octanoic acid and triethylene glycol
Constituent 1
- Specific details on test material used for the study:
- The test substance was received from the C.P. Hall Company on July 5, 1995. The BIN number was 024910
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Wistar-strain, albino rats were used for this test. Animals were obtained from Ace Animals, Inc., in Boyertown, PA., in equal numbers of each sex, between 200 and 300 grams bodyweight, and approximately six to nine (6 to 9) weeks of age.
Upon receipt, animals were carefully checked for respiratory difficulty, ocular or nasal lacrimation, dehydration, diarrhea, and general condition.
Animals were acclimated for eight (8) days prior to test initiation. They were housed in stainless steel cages with indirect bedding, in a room with a 12 hour light/dark cycle. The room temperature was controlled, to provide for the health and comfort of the animals with an approximate range of 65° to 75° F. The humidity was also monitored. Diet consisted of Lab Diet Certified Rodent Diet #5002, as well as water, ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Rats received a single bolus dose by oral gavage at a calculated dose of 5,000 mg/kg bw.
- Doses:
- A single 5,000 mg/kg bw dose was administered.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Prior to test initiation, the test article's mass to volume relationship (specific gravity) was determined to facilitate volumetric dosing.
Twenty-four (24) hours prior to test initiation, the rats were reexamined for general condition as described above. A group of five (5) male and five (5) female rats, of sufficient weight to assure a fasted bodyweight between 200 and 300 grams, was labelled and set aside.
The following day, after approximately 18 hours of fasting, each rat was weighed and marked with an ear clip. The weight variation of animals used did not exceed +20% of the mean weight for each sex. Individual doses, calculated on the basis of bodyweight, were administered using a stainless steel intragastric feeding needle, of sufficient bore to allow even passage of the test article. Rats were then returned to their cages, where food and water were available ad libitum. Each cage was labelled uniquely with respect to job number, test article, dose level, sex, animal number(s), and date of dosing.
Animals were observed for signs of pharmacologic activity and drug toxicity at 1, 3, 6, and 24 hours post-dosage. Observations were made at least once daily thereafter for a total of 14 days. Interim bodyweights were recorded on day seven (7).
Animals sacrificed at the end of the 14 day observation period were subjected to complete gross necropsy, with all findings noted. Sacrificing was accomplished via carbon dioxide asphyxiation. - Statistics:
- Not stated
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None recorded
- Clinical signs:
- other: No adverse clinical signs were reported. All rats reported as normal at all observation points.
- Gross pathology:
- No gross changes observed.
Any other information on results incl. tables
Acute Oral Toxicity in Rats - Bodyweights
Dose Level: 5,000 mg/kg bw
Animal Number and Sex |
Bodyweight (grams) |
Day 7 |
Termanal |
Change (+/-) |
1 M |
230 |
309 |
344 |
+114 |
2 M |
218 |
305 |
338 |
+120 |
3 M |
237 |
307 |
340 |
+103 |
4 M |
228 |
300 |
332 |
+104 |
5 M |
233 |
342 |
384 |
+151 |
6 F |
220 |
262 |
282 |
+62 |
7 F |
218 |
251 |
264 |
+46 |
8 F |
224 |
262 |
284 |
+60 |
9 F |
246 |
264 |
270 |
+24 |
10 F |
236 |
243 |
260 |
+24 |
Applicant's summary and conclusion
- Conclusions:
- The acute oral LD50 in male and female rats is > 5,000 mg/kg bw.
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