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Diss Factsheets
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EC number: 232-452-1 | CAS number: 8031-44-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Endpoint addressed:
- skin irritation / corrosion
- skin sensitisation
- Principles of method if other than guideline:
- The dermal tolerability of the substance was assessed in human volunteers.
- GLP compliance:
- no
Test material
- Reference substance name:
- Lanolin, hydrogenated
- EC Number:
- 232-452-1
- EC Name:
- Lanolin, hydrogenated
- Cas Number:
- 8031-44-5
- Molecular formula:
- UVCB: not available
- IUPAC Name:
- Lanolin, wool wax, hydrogenated
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- 14 subjects age 24-44 years participated (voluntarily) in this study. The substance was melted by using bain-marie.
The tested site was controlled after 24 and 48 hours by the same doctor and possible skin reactions such as erythema were noted (as present or absent). - Exposure assessment:
- not specified
- Details on exposure:
- For the application of the substance, a gauze of 4 cm2 was soaked with appr. 25 grams of the melted substance, and once cooled, it was applied on the palm. This gauze was then covered by another bigger gauze and it was fixed on the palm witn a patch tape.
Results and discussion
- Results:
- No evidence of dermal intolerance of the substance was noted. None of the subjects complained for itching or any other indications of intolerance.
Applicant's summary and conclusion
- Conclusions:
- The test material is tolerable by the human volunteers.
- Executive summary:
The substance was evaluated for its dermal tolerability on human volunteers. For this reason, 14 subjects age 24 -44 years were subjected to a dermal application of the test substance on the palm. The tested site was controlled after 24 and 48 hours by the same doctor and possible skin reactions such as erythema were noted (as present or absent).
No evidence of dermal intolerance of the substance was noted. None of the subjects complained for itching or any other indications of intolerance.
The test material is tolerable by the human volunteers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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