Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes
Limit test:
no

Test animals

Species:
other: Rat (Wistar strain Crl: (WI) BR)

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: 1% Aqueous carboxymethyl cellulose.
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
No deaths occurred and no clinical signs indicative of
systemic toxicity were noted in any of the animals.
Gross pathology:
Effects on organs:
Macroscopic examination revealed a colon distended with gas
in one male and two females. A caecum distended with gas was
noted in two females. The other animals did not reveal any
abnormalities.
Other findings:
Signs of toxicity (local):
Yellow staining caused by the test substance was seen in the
treated skin-area of all animals during the observation
period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU