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EC number: 264-391-1 | CAS number: 63663-21-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 January 2018 to 15 January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 12.57 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 6 - <= 7
- Remarks on result:
- other: 12.57 ± 0.48 μg/L
- Details on results:
- - The deviation among the 5 parallel results of the columns were less than 30 % and random fashioned so all the 10 values were averaged and the standard deviation calculated. The solubility is given as mean ± SD.
- The water solubility of the test material is 12.57 ± 0.48 μg/L at 20±0.5 °C. - Conclusions:
- Under the conditions of this study, the water solubility of the test material was 12.57 ± 0.48 μg/L at 20 ± 0.5 °C.
- Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions.
The test material was dissolved in HPLC tetrahydrofuran and mixed with glass beads. The solvent was evaporated and the covered glass beads were filled into the microcolumns. The bed- and headvolumes were determined and the recirculating pumps set to approx. 25 and 12.5 mL. The systems were equilibrated at 20 °C for 2 hours and five bed volumes of water was discarded. The systems were filled up to head volumes and the recirculation started. After 4 days the sampling started. The samples were filtered through 0.45 μm membrane filter. 150 μL from the filtrate was mixed with 150 μL methanol. Each sample was prepared in duplicate. The pH was measured by indicator strip. The samples were analysed.
Under the conditions of this study, the water solubility of the test material was 12.57 ± 0.48 μg/L at 20 ± 0.5 °C.
Reference
Table 1: Results of the solubility measurements
Day |
Time |
Column 1 |
Column 2 |
||||
pH |
Test Material Conc. (μg/L) |
Deviation (%) |
pH |
Test Material Conc (μg/L) |
Deviation (%) |
||
4 |
07.18 |
6-7 |
13.03 |
9.75 |
6-7 |
12.79 |
10.62 |
4 |
16.51 |
6-7 |
12.63 |
6-7 |
12.98 |
||
5 |
09.26 |
6-7 |
11.87 |
6-7 |
11.92 |
||
5 |
19.31 |
6-7 |
12.63 |
6-7 |
12.73 |
||
7 |
05.51 |
6-7 |
12.00 |
6-7 |
13.18 |
||
Mean |
12.43 |
|
12.72 |
|
Description of key information
Under the conditions of this study, the water solubility of the test material was 12.57 ± 0.48 μg/L at 20 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 12.57 µg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The test material was dissolved in HPLC tetrahydrofuran and mixed with glass beads. The solvent was evaporated and the covered glass beads were filled into the microcolumns. The bed- and headvolumes were determined and the recirculating pumps set to approx. 25 and 12.5 mL. The systems were equilibrated at 20 °C for 2 hours and five bed volumes of water was discarded. The systems were filled up to head volumes and the recirculation started. After 4 days the sampling started. The samples were filtered through 0.45 μm membrane filter. 150 μL from the filtrate was mixed with 150 μL methanol. Each sample was prepared in duplicate. The pH was measured by indicator strip. The samples were analysed.
Under the conditions of this study, the water solubility of the test material was 12.57 ± 0.48 μg/L at 20 ± 0.5 °C.
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