Registration Dossier
Registration Dossier
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EC number: 208-849-0 | CAS number: 543-80-6
Endpoint summary
Administrative data
Description of key information
Additional information
Metal acetates are substances consisting of a metal and acetic acid. Based on the solubility of barium di(acetate) in water (792 g barium di(acetate)/L), a complete dissociation of barium di(acetate) resulting in barium and acetate ions may be assumed under environmental conditions.
A bioconcentration study with acetic acid (CAS #64-19-7) was not considered to be required since the substance has a low potential for bioaccumulation based on a calculated partition-coefficient of -0.17 (EpiSuite v.4.1; external database). Therefore, acetic acid is expected to exhibit a low potential to bioaccumulate in aquatic ecosystems.
Regarding the potential of barium available data suggest that barium bioconcentration and bioaccumulation is negligible: the bioaccumulation factor of fish (whole body) was situated between 37.6 and 98.8 (geomean of 4 values: 65.6) (Nakamoto and Hassler, 1992). Whole-body concentrations are significantly higher than reported soft tissue concentrations due to the fact that barium can replace calcium in the bones and hard tissue parts; indeed, according to the WHO (1990), approximately 91% of barium found in the body are located in the bones. Reported whole-body Ba-levels in fish were similar in different studies; the following ranges were reported; 5.7-17.2 μg/g (Nakamoto and Hassler, 1992), 4.37 μg/g (Saiki and Palawski, 1990); 5.1-16 μg/g (Schroeder et al, 1988); 4.4-12 (Radtke et al, 1988) and 9-33 μg/g (three fish species; Allen et al, 2001). The data indicate a certain degree of homeostatic control of internal barium levels by fish. Limited information on transfer of barium through the food chain indicates that barium does not biomagnify in aquatic food chains. Therefore, it can be considered that barium has a low potential to bioconcentrate or bioaccumulate in aquatic organisms.
Hence, based on information for barium and acetate, barium di(acetate) is expected to have a low potential to bioaccumulate in aquatic and terrestrial organisms.
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