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Diss Factsheets
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EC number: 947-646-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed by a GLP accredited laboratory although this study was not performed to GLP. The procedures used in the study were based on EEC methodology and are sufficient to conclude on the classification and labelling of the substance.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Two male and two female rats were dosed by gavage with 2000 mg/kg bodyweight of undiluted test material.
Body weights and clinical signs were observed.
Macroscopic examinations of all animals was performed at study termination. - GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of mixed xylenes and sulphur monochloride
- IUPAC Name:
- Reaction mass of mixed xylenes and sulphur monochloride
- Reference substance name:
- DXDS
- IUPAC Name:
- DXDS
- Details on test material:
- - Name of test material (as cited in study report): DXDS (Dixylyldisulphide)
- Physical state: Liquid
- Analytical purity: Approximately 100%
- Purity test date: 04/07/1995
- Lot/batch No.: SMD95/14
- Expiration date of the lot/batch: 6th Jan 1996
- Storage condition of test material: Room temperature in the dark
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg bodyweight
- No. of animals per sex per dose:
- 2 male/ 2 female animals per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations and weighing: Animals weighed on day 1 and day 8 of the study.
- Necropsy of survivors performed: No
- Other examinations performed: Clinical signs and bodyweights were recorded.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died during the study.
- Clinical signs:
- Signs of piloerection were observed in all four animals in the study, hunched posture and waddling were observed in both male animals.
- Body weight:
- Bodyweights were recorded on day 1 and day 8. The male animals increased body weight by 82 and 75 grams, the females increased bodyweight by 48 and 47 grams over the study period. No data is available for a control, however the report states that bodyweight gains were satisfactiory for a study of this nature.
- Gross pathology:
- No macroscopic abnormalities were detected in any animal.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The study concludes that the acute oral LD50 for the reaction mass of mixed xylenes and sulphur monochloride is greater than 2000 mg/kg bodyweight. No classification for acute oral toxicity is required.
- Executive summary:
A non-GLP study was performed to determine the effect of DXDS on the rat when dosed orally. Two male and two female rats were dosed by gavage with 2000 mg/kg bodyweight of the test substance. Clinical signs and bodyweight were recorded. Signs of piloerection were observed in all four animals, hunched posture and waddling were observed in both male animals. Bodyweight gains were considered acceptable and no macroscopic abnormalities were observed in any animal. No mortalities were observed.
Based on the results of the study, the acute oral LD50 for DXDS in the rat is greater than 2000 mg/kg bodyweight. No classification with respect to oral toxicity is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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