Registration Dossier
Registration Dossier
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EC number: 217-210-5 | CAS number: 1777-82-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June to August 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental study with basic information given
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was administered to rats orally once and obseration was done for 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4-dichlorobenzyl alcohol
- EC Number:
- 217-210-5
- EC Name:
- 2,4-dichlorobenzyl alcohol
- Cas Number:
- 1777-82-8
- Molecular formula:
- C7H6Cl2O
- IUPAC Name:
- (2,4-dichlorophenyl)methanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Boots wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 70-95 g
- Fasting period before study: 4 h
- Housing: 10 per cage
- Diet: ad libitum, Oxoid Breeding Diet
- Water: ad libitum, tap water
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 10 % (w/v) aqueous acacia solution.
- Details on oral exposure:
- VEHICLE
- Amount of vehicle: 0.2 mL /100 g - Doses:
- approx. 3000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation was done for 2 h after dosing and afterwards daily.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Mortality:
- 3 male animals died within 24 h after treatment.
- Clinical signs:
- Signs were detected soon after treatment.
Following signs were detected: Coma (1 male), prostration (1 male), inactivity (8 male, 10 female), ataxi (8 male, 10 female), slow respiration (2 male) - Body weight:
- No data.
- Gross pathology:
- No abnormalities were detected during autopsy in 10 female and 7 male animals. The 3 male animals that died after treatmen were not examined due to autolysis.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
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