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Diss Factsheets
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EC number: 213-914-1 | CAS number: 1066-40-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable short-term toxicity tests results are available for the effects of HMDS on freshwater fish (Oncorhynchus mykiss), and algae (Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata)). Short-term studies for invertebrates (Daphnia magna) exist but were not considered to be reliable. However, in accordance with Column 2 specific rules for adaptation from Column 1 of Annex VII of the REACH Regulation, the short-term invertebrate study does not need to be conducted because a long-term aquatic toxicity study on invertebrates is available.
A 96-hour LC50 value of 0.46 mg/l (expressed as measured concentration) has been determined for effects on mortality of O. mykiss.
A 70-hour ErC50 value of >0.55 mg/l and ErC10 of 0.09 mg/l have been determined for the effects of the substance on growth rate of S. capricornutum.
In a longer-term test a 21-day EC50 value of 0.30 mg/l and NOEC of 0.08 mg/l have been determined for the effects of the substance on reproduction of Daphnia magna.
No reliable experimental test results are available for long-term toxicity of HMDS to fish. A read-across 90-day NOEC of ≥27 μg/l (0.027 mg/l) has been determined for the effects of structurally-similar substance octamethyltrisiloxane on early-life stages of Oncorhynchus mykiss.
Three reliable studies are available for toxicity to microorganisms.
Two reliable studies are ASRI (activated sludge respiration inhibition) studies. The key study was chosen as the most recent study. This study gave a result of NOEC (3 h) ≥100 mg/l; EC50 >100 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.